CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline
Emerging evidence suggests that immune receptors may participate in many aging-related processes such as energy metabolism, inflammation, and cognitive decline. CD300f, a TREM2-like lipid-sensing immune receptor, is an exceptional receptor as it integrates activating and inhibitory cell-signaling pa...
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| Формат: | article |
| Мова: | Англійська |
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2023
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| Онлайн доступ: | https://hdl.handle.net/20.500.12008/43331 |
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| _version_ | 1868890110286626816 |
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| author | Evans Isola, Frances |
| author2 | Alí Ruiz, Daniela Rego, Natalia Negro Demontel, María Luciana Lago, Natalia Cawen Curbelo, Fabio Andrés Pannunzio, Bruno Sánchez-Molina, Paula Reyes Ábalos, Ana Laura Paolino, Andrea Rodríguez Duarte, Jorge Pérez Torrado, María Valentina Chicote-González, Almudena Quijano, Celia Marmisolle, Inés Mulet, Ana Paula Schlapp, Geraldine Meikle, María Noel Bresque, Mariana Crispo, Martina Savio, Eduardo Malagelada, Cristina Escande, Carlos Peluffo, Hugo |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author |
| author_browse | Alí Ruiz, Daniela Bresque, Mariana Cawen Curbelo, Fabio Andrés Chicote-González, Almudena Crispo, Martina Escande, Carlos Evans Isola, Frances Lago, Natalia Malagelada, Cristina Marmisolle, Inés Meikle, María Noel Mulet, Ana Paula Negro Demontel, María Luciana Pannunzio, Bruno Paolino, Andrea Peluffo, Hugo Pérez Torrado, María Valentina Quijano, Celia Rego, Natalia Reyes Ábalos, Ana Laura Rodríguez Duarte, Jorge Savio, Eduardo Schlapp, Geraldine Sánchez-Molina, Paula |
| author_facet | Evans Isola, Frances Alí Ruiz, Daniela Rego, Natalia Negro Demontel, María Luciana Lago, Natalia Cawen Curbelo, Fabio Andrés Pannunzio, Bruno Sánchez-Molina, Paula Reyes Ábalos, Ana Laura Paolino, Andrea Rodríguez Duarte, Jorge Pérez Torrado, María Valentina Chicote-González, Almudena Quijano, Celia Marmisolle, Inés Mulet, Ana Paula Schlapp, Geraldine Meikle, María Noel Bresque, Mariana Crispo, Martina Savio, Eduardo Malagelada, Cristina Escande, Carlos Peluffo, Hugo |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Evans Isola Frances, Universidad de la República (Uruguay). Facultad de Medicina. Alí Ruiz Daniela, Instituto Pasteur (Montevideo). Rego Natalia, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Negro Demontel María Luciana, Universidad de la República (Uruguay). Facultad de Medicina. Lago Natalia, Instituto Pasteur (Montevideo). Cawen Curbelo Fabio Andrés, Instituto Pasteur (Montevideo). Pannunzio Bruno, Universidad de la República (Uruguay). Facultad de Medicina. Sánchez-Molina Paula Reyes Ábalos Ana Laura, CUDIM Paolino Andrea, CUDIM Rodríguez Duarte Jorge, Instituto Pasteur (Montevideo). Pérez Torrado María Valentina, Instituto Pasteur (Montevideo). Chicote-González Almudena Quijano Celia, Universidad de la República (Uruguay). Facultad de Medicina. Marmisolle Inés, Universidad de la República (Uruguay). Facultad de Medicina. Mulet Ana Paula, Instituto Pasteur (Montevideo). Schlapp Geraldine, Instituto Pasteur (Montevideo). Meikle María Noel, Instituto Pasteur (Montevideo). Bresque Mariana, Instituto Pasteur (Montevideo). Crispo Martina, Instituto Pasteur (Montevideo). Savio Eduardo, CUDIM Malagelada Cristina Escande Carlos, Instituto Pasteur (Montevideo). Peluffo Hugo, Universidad de la República (Uruguay). Facultad de Medicina. |
| dc.creator.none.fl_str_mv | Evans Isola, Frances Alí Ruiz, Daniela Rego, Natalia Negro Demontel, María Luciana Lago, Natalia Cawen Curbelo, Fabio Andrés Pannunzio, Bruno Sánchez-Molina, Paula Reyes Ábalos, Ana Laura Paolino, Andrea Rodríguez Duarte, Jorge Pérez Torrado, María Valentina Chicote-González, Almudena Quijano, Celia Marmisolle, Inés Mulet, Ana Paula Schlapp, Geraldine Meikle, María Noel Bresque, Mariana Crispo, Martina Savio, Eduardo Malagelada, Cristina Escande, Carlos Peluffo, Hugo |
| dc.date.none.fl_str_mv | 2023 2024-04-04T13:29:41Z 2024-04-04T13:29:41Z |
| dc.format.none.fl_str_mv | 24 h. application/pdf |
| dc.identifier.none.fl_str_mv | Evans Isola, F, Alí Ruiz, D, Rego, N. [y otros auores]. "CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline". Cell Reports. [en línea] 2023, 42(10): 113269. 24 h. DOI: 10.1016/j.celrep.2023.113269. 2211-1247 https://hdl.handle.net/20.500.12008/43331 10.1016/j.celrep.2023.113269 |
| dc.language.none.fl_str_mv | en eng |
| dc.publisher.none.fl_str_mv | Cell Press |
| dc.relation.none.fl_str_mv | Cell Reports, 2023, 42(10): 113269. |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Aging Microglia DAM Macrophage Immunometabolism Cognitive decline Dementia Positron emmission tomography Glucose metabolism Inflammaging Healthspan Lifespan Sex differences |
| dc.title.none.fl_str_mv | CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Emerging evidence suggests that immune receptors may participate in many aging-related processes such as energy metabolism, inflammation, and cognitive decline. CD300f, a TREM2-like lipid-sensing immune receptor, is an exceptional receptor as it integrates activating and inhibitory cell-signaling pathways that modulate inflammation, efferocytosis, and microglial metabolic fitness. We hypothesize that CD300f can regulate systemic aging-related processes and ultimately healthy lifespan. We closely followed several cohorts of two strains of CD300f / and WT mice of both sexes for 30 months and observed an important reduction in lifespan and healthspan in knockout mice. This was associated with systemic inflammaging, increased cognitive decline, reduced brain glucose uptake observed by 18FDG PET scans, enrichment in microglial aging/neurodegeneration phenotypes, proteostasis alterations, senescence, increased frailty, and sex-dependent systemic metabolic changes. Moreover, the absence of CD300f altered macrophage immunometabolic phenotype. Taken together, we provide strong evidence suggesting that myeloid cell CD300f immune receptor contributes to healthy aging. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_802f12dc2ab9bb005989c8d663ad5477 |
| identifier_str_mv | Evans Isola, F, Alí Ruiz, D, Rego, N. [y otros auores]. "CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline". Cell Reports. [en línea] 2023, 42(10): 113269. 24 h. DOI: 10.1016/j.celrep.2023.113269. 2211-1247 10.1016/j.celrep.2023.113269 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/43331 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| publisher.none.fl_str_mv | Cell Press |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive declineEvans Isola, FrancesAlí Ruiz, DanielaRego, NataliaNegro Demontel, María LucianaLago, NataliaCawen Curbelo, Fabio AndrésPannunzio, BrunoSánchez-Molina, PaulaReyes Ábalos, Ana LauraPaolino, AndreaRodríguez Duarte, JorgePérez Torrado, María ValentinaChicote-González, AlmudenaQuijano, CeliaMarmisolle, InésMulet, Ana PaulaSchlapp, GeraldineMeikle, María NoelBresque, MarianaCrispo, MartinaSavio, EduardoMalagelada, CristinaEscande, CarlosPeluffo, HugoAgingMicrogliaDAMMacrophageImmunometabolismCognitive declineDementiaPositron emmission tomographyGlucose metabolismInflammagingHealthspanLifespanSex differencesEmerging evidence suggests that immune receptors may participate in many aging-related processes such as energy metabolism, inflammation, and cognitive decline. CD300f, a TREM2-like lipid-sensing immune receptor, is an exceptional receptor as it integrates activating and inhibitory cell-signaling pathways that modulate inflammation, efferocytosis, and microglial metabolic fitness. We hypothesize that CD300f can regulate systemic aging-related processes and ultimately healthy lifespan. We closely followed several cohorts of two strains of CD300f / and WT mice of both sexes for 30 months and observed an important reduction in lifespan and healthspan in knockout mice. This was associated with systemic inflammaging, increased cognitive decline, reduced brain glucose uptake observed by 18FDG PET scans, enrichment in microglial aging/neurodegeneration phenotypes, proteostasis alterations, senescence, increased frailty, and sex-dependent systemic metabolic changes. Moreover, the absence of CD300f altered macrophage immunometabolic phenotype. Taken together, we provide strong evidence suggesting that myeloid cell CD300f immune receptor contributes to healthy aging.Cell PressEvans Isola Frances, Universidad de la República (Uruguay). Facultad de Medicina.Alí Ruiz Daniela, Instituto Pasteur (Montevideo).Rego Natalia, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Negro Demontel María Luciana, Universidad de la República (Uruguay). Facultad de Medicina.Lago Natalia, Instituto Pasteur (Montevideo).Cawen Curbelo Fabio Andrés, Instituto Pasteur (Montevideo).Pannunzio Bruno, Universidad de la República (Uruguay). Facultad de Medicina.Sánchez-Molina PaulaReyes Ábalos Ana Laura, CUDIMPaolino Andrea, CUDIMRodríguez Duarte Jorge, Instituto Pasteur (Montevideo).Pérez Torrado María Valentina, Instituto Pasteur (Montevideo).Chicote-González AlmudenaQuijano Celia, Universidad de la República (Uruguay). Facultad de Medicina.Marmisolle Inés, Universidad de la República (Uruguay). Facultad de Medicina.Mulet Ana Paula, Instituto Pasteur (Montevideo).Schlapp Geraldine, Instituto Pasteur (Montevideo).Meikle María Noel, Instituto Pasteur (Montevideo).Bresque Mariana, Instituto Pasteur (Montevideo).Crispo Martina, Instituto Pasteur (Montevideo).Savio Eduardo, CUDIMMalagelada CristinaEscande Carlos, Instituto Pasteur (Montevideo).Peluffo Hugo, Universidad de la República (Uruguay). Facultad de Medicina.2024-04-04T13:29:41Z2024-04-04T13:29:41Z2023Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion24 h.application/pdfEvans Isola, F, Alí Ruiz, D, Rego, N. [y otros auores]. "CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline". Cell Reports. [en línea] 2023, 42(10): 113269. 24 h. DOI: 10.1016/j.celrep.2023.113269.2211-1247https://hdl.handle.net/20.500.12008/4333110.1016/j.celrep.2023.113269reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengCell Reports, 2023, 42(10): 113269.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)oai:colibri.udelar.edu.uy:20.500.12008/433312026-04-14T10:10:37Z |
| spellingShingle | CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline Evans Isola, Frances Aging Microglia DAM Macrophage Immunometabolism Cognitive decline Dementia Positron emmission tomography Glucose metabolism Inflammaging Healthspan Lifespan Sex differences |
| status_str | publishedVersion |
| title | CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline |
| title_full | CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline |
| title_fullStr | CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline |
| title_full_unstemmed | CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline |
| title_short | CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline |
| title_sort | CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline |
| topic | Aging Microglia DAM Macrophage Immunometabolism Cognitive decline Dementia Positron emmission tomography Glucose metabolism Inflammaging Healthspan Lifespan Sex differences |
| url | https://hdl.handle.net/20.500.12008/43331 |