Patients with advanced oral squamous cell carcinoma have high levels of soluble E-cadherin in the saliva
Background: The objective of this study was to assess the potential clinical value of the concentration of soluble salivary E-cadherin (sE-cadherin) compared with the clinical value of the presence of membranous E-cadherin (mE-cadherin) in oral squamous cell carcinoma tumor tissues. Material and Met...
Saved in:
| Hovedforfatter: | |
|---|---|
| Andre forfattere: | , , , , , , , |
| Format: | article |
| Sprog: | engelsk |
| Udgivet: |
2017
|
| Fag: | |
| Online adgang: | http://hdl.handle.net/20.500.12008/18473 |
| Tags: |
Ingen Tags, Vær først til at tagge denne postø!
|
| _version_ | 1868890097919721472 |
|---|---|
| author | López-Verdín, Sandra |
| author2 | Soto Avila, Juan José Zamora Pérez, Ana Lourdes Lazalde Ramos, Blanca Patricia Martínez Fierro, Margarita de la Luz González González, Rogelio Molina-Frechero, Nelly Isiordia-Espinoza, Mario Alberto Bologna-Molina, Ronell |
| author2_role | author author author author author author author author |
| author_browse | Bologna-Molina, Ronell González González, Rogelio Isiordia-Espinoza, Mario Alberto Lazalde Ramos, Blanca Patricia López-Verdín, Sandra Martínez Fierro, Margarita de la Luz Molina-Frechero, Nelly Soto Avila, Juan José Zamora Pérez, Ana Lourdes |
| author_facet | López-Verdín, Sandra Soto Avila, Juan José Zamora Pérez, Ana Lourdes Lazalde Ramos, Blanca Patricia Martínez Fierro, Margarita de la Luz González González, Rogelio Molina-Frechero, Nelly Isiordia-Espinoza, Mario Alberto Bologna-Molina, Ronell |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Lopez-Verdín S, Universidad de Guadalajara (México) Soto-Avila JJ, Instituto Jalisciense de Cancerología (México) Zamora-Pérez AL, Universidad de Guadalajara (México) Lazalde-Ramos BP, Universidad Autónoma de Zacatecas (México) Martínez-Fierro M de la Luz, Universidad Autónoma de Zacatecas (México) González-González R., Universidad Juárez del Estado de Durango (México) Molina-Frechero N., Universidad Autónoma Metropolitana (Mexico) Isiordia-Espinoza MA, Universidad Autónoma de San Luis Potosí (México) Bologna-Molina Ronell, Universidad de la República (Uruguay). Facultad de Odontología |
| dc.creator.none.fl_str_mv | López-Verdín, Sandra Soto Avila, Juan José Zamora Pérez, Ana Lourdes Lazalde Ramos, Blanca Patricia Martínez Fierro, Margarita de la Luz González González, Rogelio Molina-Frechero, Nelly Isiordia-Espinoza, Mario Alberto Bologna-Molina, Ronell |
| dc.date.none.fl_str_mv | 2017 2018-10-08T20:38:41Z 2018-10-08T20:38:41Z |
| dc.format.none.fl_str_mv | 8 h. application/pdf |
| dc.identifier.none.fl_str_mv | Lopez-Verdín, S, Soto-Avila, J, Zamora-Pérez, A, Lazalde-Ramos, B, Martínez-Fierro, M, González-González, R, Molina-Frechero, N, Isiordia-Espinoza, M y Bologna-Molina, R. "Patients with advanced oral squamous cell carcinoma have high levels of soluble E-cadherin in the saliva". Med Oral Patol Oral Cir Bucal [en línea] 2017, 22 (6):694-701. 698-6946 doi:10.4317/medoral.21907 http://hdl.handle.net/20.500.12008/18473 |
| dc.language.none.fl_str_mv | en eng |
| dc.relation.none.fl_str_mv | Med Oral Patol Oral Cir Bucal, 2017, 22 (6):694-701 |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | E-cadher.in Saliva Oral cancer |
| dc.title.none.fl_str_mv | Patients with advanced oral squamous cell carcinoma have high levels of soluble E-cadherin in the saliva |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Background: The objective of this study was to assess the potential clinical value of the concentration of soluble salivary E-cadherin (sE-cadherin) compared with the clinical value of the presence of membranous E-cadherin (mE-cadherin) in oral squamous cell carcinoma tumor tissues. Material and Methods: Data regarding patient demographics, clinical stage, saliva and tumor tissue samples were collected. The saliva was analyzed for sE-cadherin protein levels and was compared to the mE-cadherin immunohistochemical expression levels in tumor tissues, which were assessed via the HercepTest® method. Patients without cancer were included in the study as a control group for comparisons of the sE-cadherin levels. Results: sE-cadherin levels in the saliva of patients without cancer were lower than those in patients with cancer, and the difference was statistically significant (p=0.031). Low mE-cadherin expression was statistically significantly associated with lymph node positivity (p=0.015) and advanced clinical stage (p=0.001). The inverse relationship between mE-cadherin and sE-cadherin was significant in terms of lymph node positivity (p=0.014) and advanced clinical stage (p=0.037). Conclusions: The results suggest that sE-cadherin levels are significantly increased in patients with oral cancer and that its low expression within the membrane as well as the progression of the disease appear to be inversely associated with levels of sE-cadherin in the saliva. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_75fb4080f63f3e4b5b44f516042cc5ee |
| identifier_str_mv | Lopez-Verdín, S, Soto-Avila, J, Zamora-Pérez, A, Lazalde-Ramos, B, Martínez-Fierro, M, González-González, R, Molina-Frechero, N, Isiordia-Espinoza, M y Bologna-Molina, R. "Patients with advanced oral squamous cell carcinoma have high levels of soluble E-cadherin in the saliva". Med Oral Patol Oral Cir Bucal [en línea] 2017, 22 (6):694-701. 698-6946 doi:10.4317/medoral.21907 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/18473 |
| publishDate | 2017 |
| publishDateSort | 2017 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Patients with advanced oral squamous cell carcinoma have high levels of soluble E-cadherin in the salivaLópez-Verdín, SandraSoto Avila, Juan JoséZamora Pérez, Ana LourdesLazalde Ramos, Blanca PatriciaMartínez Fierro, Margarita de la LuzGonzález González, RogelioMolina-Frechero, NellyIsiordia-Espinoza, Mario AlbertoBologna-Molina, RonellE-cadher.inSalivaOral cancerBackground: The objective of this study was to assess the potential clinical value of the concentration of soluble salivary E-cadherin (sE-cadherin) compared with the clinical value of the presence of membranous E-cadherin (mE-cadherin) in oral squamous cell carcinoma tumor tissues. Material and Methods: Data regarding patient demographics, clinical stage, saliva and tumor tissue samples were collected. The saliva was analyzed for sE-cadherin protein levels and was compared to the mE-cadherin immunohistochemical expression levels in tumor tissues, which were assessed via the HercepTest® method. Patients without cancer were included in the study as a control group for comparisons of the sE-cadherin levels. Results: sE-cadherin levels in the saliva of patients without cancer were lower than those in patients with cancer, and the difference was statistically significant (p=0.031). Low mE-cadherin expression was statistically significantly associated with lymph node positivity (p=0.015) and advanced clinical stage (p=0.001). The inverse relationship between mE-cadherin and sE-cadherin was significant in terms of lymph node positivity (p=0.014) and advanced clinical stage (p=0.037). Conclusions: The results suggest that sE-cadherin levels are significantly increased in patients with oral cancer and that its low expression within the membrane as well as the progression of the disease appear to be inversely associated with levels of sE-cadherin in the saliva.Lopez-Verdín S, Universidad de Guadalajara (México)Soto-Avila JJ, Instituto Jalisciense de Cancerología (México)Zamora-Pérez AL, Universidad de Guadalajara (México)Lazalde-Ramos BP, Universidad Autónoma de Zacatecas (México)Martínez-Fierro M de la Luz, Universidad Autónoma de Zacatecas (México)González-González R., Universidad Juárez del Estado de Durango (México)Molina-Frechero N., Universidad Autónoma Metropolitana (Mexico)Isiordia-Espinoza MA, Universidad Autónoma de San Luis Potosí (México)Bologna-Molina Ronell, Universidad de la República (Uruguay). Facultad de Odontología2018-10-08T20:38:41Z2018-10-08T20:38:41Z2017Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion8 h.application/pdfLopez-Verdín, S, Soto-Avila, J, Zamora-Pérez, A, Lazalde-Ramos, B, Martínez-Fierro, M, González-González, R, Molina-Frechero, N, Isiordia-Espinoza, M y Bologna-Molina, R. "Patients with advanced oral squamous cell carcinoma have high levels of soluble E-cadherin in the saliva". Med Oral Patol Oral Cir Bucal [en línea] 2017, 22 (6):694-701.698-6946doi:10.4317/medoral.21907http://hdl.handle.net/20.500.12008/18473reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengMed Oral Patol Oral Cir Bucal, 2017, 22 (6):694-701Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessoai:colibri.udelar.edu.uy:20.500.12008/184732026-04-14T10:16:30Z |
| spellingShingle | Patients with advanced oral squamous cell carcinoma have high levels of soluble E-cadherin in the saliva López-Verdín, Sandra E-cadher.in Saliva Oral cancer |
| status_str | publishedVersion |
| title | Patients with advanced oral squamous cell carcinoma have high levels of soluble E-cadherin in the saliva |
| title_full | Patients with advanced oral squamous cell carcinoma have high levels of soluble E-cadherin in the saliva |
| title_fullStr | Patients with advanced oral squamous cell carcinoma have high levels of soluble E-cadherin in the saliva |
| title_full_unstemmed | Patients with advanced oral squamous cell carcinoma have high levels of soluble E-cadherin in the saliva |
| title_short | Patients with advanced oral squamous cell carcinoma have high levels of soluble E-cadherin in the saliva |
| title_sort | Patients with advanced oral squamous cell carcinoma have high levels of soluble E-cadherin in the saliva |
| topic | E-cadher.in Saliva Oral cancer |
| url | http://hdl.handle.net/20.500.12008/18473 |