Primordial odontogenic tumor : A systematic review
Background: The primordial odontogenic tumor (POT) is a recently described benign entity with histopathological and immunohistochemical features suggesting its origin during early odontogenesis. Aim: To integrate the available data published on POT into a comprehensive analysis to better define its...
I tiakina i:
| Kaituhi matua: | |
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| Ētahi atu kaituhi: | , , , |
| Hōputu: | article |
| Reo: | Ingarihi |
| I whakaputaina: |
2020
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| Ngā marau: | |
| Urunga tuihono: | https://hdl.handle.net/20.500.12008/25939 |
| Ngā Tūtohu: |
Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
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| _version_ | 1868890092165136384 |
|---|---|
| author | Bologna-Molina, Ronell |
| author2 | Mosqueda Taylor, Adalberto Pereira-Prado, Vanesa Sánchez-Romero, Celeste González González, Rogelio |
| author2_role | author author author author |
| author_browse | Bologna-Molina, Ronell González González, Rogelio Mosqueda Taylor, Adalberto Pereira-Prado, Vanesa Sánchez-Romero, Celeste |
| author_facet | Bologna-Molina, Ronell Mosqueda Taylor, Adalberto Pereira-Prado, Vanesa Sánchez-Romero, Celeste González González, Rogelio |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Bologna-Molina Ronell, Universidad de la República (Uruguay). Facultad de Odontología Mosqueda Taylor Adalberto Pereira-Prado Vanesa, Universidad de la República (Uruguay). Facultad de Odontología Sánchez-Romero Celeste, Universidad de la República (Uruguay). Facultad de Odontología González González Rogelio |
| dc.creator.none.fl_str_mv | Bologna-Molina, Ronell Mosqueda Taylor, Adalberto Pereira-Prado, Vanesa Sánchez-Romero, Celeste González González, Rogelio |
| dc.date.none.fl_str_mv | 2020-11-24T16:27:52Z 2020-11-24T16:27:52Z 2020 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Bologna-Molina, R, Mosqueda Taylor, A, Pereira-Prado, V, y otros. "Primordial odontogenic tumor : A systematic review". Medicina Oral, Patología Bucal y Cirugía Bucal.[en línea] 2020, May; 25(3): e388–e394. doi:10.4317/medoral.23432 1698-6946 https://hdl.handle.net/20.500.12008/25939 doi:10.4317/medoral.23432 |
| dc.language.none.fl_str_mv | en eng |
| dc.relation.none.fl_str_mv | Medicina Oral, Patología oral y Cirugía Bucal, 2020, May; 25(3): e388–e394. |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Primordial odontogenic tumor Systematic review |
| dc.title.none.fl_str_mv | Primordial odontogenic tumor : A systematic review |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Background: The primordial odontogenic tumor (POT) is a recently described benign entity with histopathological and immunohistochemical features suggesting its origin during early odontogenesis. Aim: To integrate the available data published on POT into a comprehensive analysis to better define its clinicopathological and molecular features. Material and Methods: An electronic systematic review was performed up to September 2019 in multiple databases. Results: A total of 13 publications were included, representing 16 reported cases and 3 molecular studies. The mean age of the affected patients was 11.6 years (range 2-19), with a slight predominance in males (56.25%). The posterior mandible was the main location (87.5%), with only two cases affecting the posterior maxilla. All cases appeared as a radiolucent lesion in close relationship to an unerupted tooth. Recurrences have not been reported to date. Microscopically, POT comprises fibromyxoid tissue with variable cellularity surrounded by a cuboidal to columnar odontogenic epithelium but without unequivocal dental hard tissue formation. A delicate fibrous capsule surrounds (at least partially) the tumor. The epithelial component shows immunohistochemical positivity for amelogenin, CK19, and CK14, and variable expression of Glut-1, Galectin-3 and Caveolin-1, Vimentin, p-53, PITX2, Bcl-2, Bax and Survivin; the mesenchymal tissue is positive for Vimentin, CD90, p-53, PITX2, Bcl-2, Bax, and Survivin, and the subepithelial region exhibits the strong expression of Syndecan-1 and CD34. The Ki-67 index is low (<5%). The negative or weak expression of dentinogenesis-associated genes could explain the inhibition of dentin and subsequent enamel formation in this neoplasm. Conclusion: POT is an entity with a well-defined clinicopathological, immunohistochemical and molecular profile that must be properly diagnosed and differentiated from other odontogenic lesions and treated consequently. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_6efd5ec26cb2efe18391c18210e2d6a8 |
| identifier_str_mv | Bologna-Molina, R, Mosqueda Taylor, A, Pereira-Prado, V, y otros. "Primordial odontogenic tumor : A systematic review". Medicina Oral, Patología Bucal y Cirugía Bucal.[en línea] 2020, May; 25(3): e388–e394. doi:10.4317/medoral.23432 1698-6946 doi:10.4317/medoral.23432 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/25939 |
| publishDate | 2020 |
| publishDateSort | 2020 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0) |
| spelling | Primordial odontogenic tumor : A systematic reviewBologna-Molina, RonellMosqueda Taylor, AdalbertoPereira-Prado, VanesaSánchez-Romero, CelesteGonzález González, RogelioPrimordial odontogenic tumorSystematic reviewBackground: The primordial odontogenic tumor (POT) is a recently described benign entity with histopathological and immunohistochemical features suggesting its origin during early odontogenesis. Aim: To integrate the available data published on POT into a comprehensive analysis to better define its clinicopathological and molecular features. Material and Methods: An electronic systematic review was performed up to September 2019 in multiple databases. Results: A total of 13 publications were included, representing 16 reported cases and 3 molecular studies. The mean age of the affected patients was 11.6 years (range 2-19), with a slight predominance in males (56.25%). The posterior mandible was the main location (87.5%), with only two cases affecting the posterior maxilla. All cases appeared as a radiolucent lesion in close relationship to an unerupted tooth. Recurrences have not been reported to date. Microscopically, POT comprises fibromyxoid tissue with variable cellularity surrounded by a cuboidal to columnar odontogenic epithelium but without unequivocal dental hard tissue formation. A delicate fibrous capsule surrounds (at least partially) the tumor. The epithelial component shows immunohistochemical positivity for amelogenin, CK19, and CK14, and variable expression of Glut-1, Galectin-3 and Caveolin-1, Vimentin, p-53, PITX2, Bcl-2, Bax and Survivin; the mesenchymal tissue is positive for Vimentin, CD90, p-53, PITX2, Bcl-2, Bax, and Survivin, and the subepithelial region exhibits the strong expression of Syndecan-1 and CD34. The Ki-67 index is low (<5%). The negative or weak expression of dentinogenesis-associated genes could explain the inhibition of dentin and subsequent enamel formation in this neoplasm. Conclusion: POT is an entity with a well-defined clinicopathological, immunohistochemical and molecular profile that must be properly diagnosed and differentiated from other odontogenic lesions and treated consequently.Bologna-Molina Ronell, Universidad de la República (Uruguay). Facultad de OdontologíaMosqueda Taylor AdalbertoPereira-Prado Vanesa, Universidad de la República (Uruguay). Facultad de OdontologíaSánchez-Romero Celeste, Universidad de la República (Uruguay). Facultad de OdontologíaGonzález González Rogelio2020-11-24T16:27:52Z2020-11-24T16:27:52Z2020Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfBologna-Molina, R, Mosqueda Taylor, A, Pereira-Prado, V, y otros. "Primordial odontogenic tumor : A systematic review". Medicina Oral, Patología Bucal y Cirugía Bucal.[en línea] 2020, May; 25(3): e388–e394. doi:10.4317/medoral.234321698-6946https://hdl.handle.net/20.500.12008/25939doi:10.4317/medoral.23432reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengMedicina Oral, Patología oral y Cirugía Bucal, 2020, May; 25(3): e388–e394.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0)oai:colibri.udelar.edu.uy:20.500.12008/259392026-04-14T10:37:11Z |
| spellingShingle | Primordial odontogenic tumor : A systematic review Bologna-Molina, Ronell Primordial odontogenic tumor Systematic review |
| status_str | publishedVersion |
| title | Primordial odontogenic tumor : A systematic review |
| title_full | Primordial odontogenic tumor : A systematic review |
| title_fullStr | Primordial odontogenic tumor : A systematic review |
| title_full_unstemmed | Primordial odontogenic tumor : A systematic review |
| title_short | Primordial odontogenic tumor : A systematic review |
| title_sort | Primordial odontogenic tumor : A systematic review |
| topic | Primordial odontogenic tumor Systematic review |
| url | https://hdl.handle.net/20.500.12008/25939 |