Glandular odontogenic cyst: insights into a rare and challenging lesion.

The glandular odontogenic cyst (GOC) is a rare developmental odontogenic cyst characterized by an epithelial lining resembling salivary or glandular tissue. Its aggressive behavior and potential for recurrence pose challenges in both diagnosis and management. This review consolidates current knowled...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijä: Schuch, Lauren Frenzel (author)
Muut tekijät: Silveira, Felipe Martins (author), González Umpiérrez, María Natalia (author), Beovide Cortegoso, Verónica (author), Sicco, Estefanía (author), Bologna-Molina, Ronell (author), Pereira-Prado, Vanesa (author)
Aineistotyyppi: article
Kieli:englanti
Julkaistu: 2025
Aiheet:
Linkit:https://hdl.handle.net/20.500.12008/51892
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!
_version_ 1868890080703152128
author Schuch, Lauren Frenzel
author2 Silveira, Felipe Martins
González Umpiérrez, María Natalia
Beovide Cortegoso, Verónica
Sicco, Estefanía
Bologna-Molina, Ronell
Pereira-Prado, Vanesa
author2_role author
author
author
author
author
author
author_browse Beovide Cortegoso, Verónica
Bologna-Molina, Ronell
González Umpiérrez, María Natalia
Pereira-Prado, Vanesa
Schuch, Lauren Frenzel
Sicco, Estefanía
Silveira, Felipe Martins
author_facet Schuch, Lauren Frenzel
Silveira, Felipe Martins
González Umpiérrez, María Natalia
Beovide Cortegoso, Verónica
Sicco, Estefanía
Bologna-Molina, Ronell
Pereira-Prado, Vanesa
author_role author
collection COLIBRI
dc.contributor.none.fl_str_mv Schuch Lauren Frenzel, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.
Silveira Felipe Martins, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.
González Umpiérrez María Natalia, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.
Beovide Cortegoso Verónica, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.
Sicco Estefanía, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.
Bologna-Molina Ronell, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.
Pereira-Prado Vanesa, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.
dc.creator.none.fl_str_mv Schuch, Lauren Frenzel
Silveira, Felipe Martins
González Umpiérrez, María Natalia
Beovide Cortegoso, Verónica
Sicco, Estefanía
Bologna-Molina, Ronell
Pereira-Prado, Vanesa
dc.date.none.fl_str_mv 2025-10-03T17:54:37Z
2025-10-03T17:54:37Z
2025
dc.format.none.fl_str_mv 6 h.
application/pdf
dc.identifier.none.fl_str_mv Schuch, L, Silveira, F, González Umpiérrez, M, [y otros autores]. "Glandular odontogenic cyst: insights into a rare and challenging lesion". Journal of Oral Diagnosis. [en línea] 2025, 10:e292.
2525-5711
https://hdl.handle.net/20.500.12008/51892
10.5327/2525-5711.292
dc.language.none.fl_str_mv en_US
eng
dc.publisher.none.fl_str_mv Brazilian Society of Oral Medicine and Oral Pathology (SOBEP).
dc.relation.none.fl_str_mv Journal of Oral Diagnosis, 2025, 10:e292.
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Licencia Creative Commons Atribución (CC - By 4.0)
dc.source.none.fl_str_mv reponame:COLIBRI
instname:Universidad de la República
instacron:Universidad de la República
dc.subject.none.fl_str_mv Odontogenic lesion
Glandular odontogenic cyst
Diagnostic challenge
QUISTES ODONTOGÉNICOS
ODONTOGENIC CYSTS
dc.title.none.fl_str_mv Glandular odontogenic cyst: insights into a rare and challenging lesion.
dc.type.none.fl_str_mv Artículo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
description The glandular odontogenic cyst (GOC) is a rare developmental odontogenic cyst characterized by an epithelial lining resembling salivary or glandular tissue. Its aggressive behavior and potential for recurrence pose challenges in both diagnosis and management. This review consolidates current knowledge on etiopathogenesis, clinical presentation, histopathological features, and treatment approaches. GOC primarily affects male adults, often presenting asymptomatically, and is most commonly found in the mandible. Radiographically, it appears as a unilocular or multilocular radiolucency, frequently associated with unerupted teeth. Histologically, GOC is istinguished by a multilocular cystic structure lined with epithelial cells, which may include “hobnail,” clear, and mucous cells. While traditionally thought to lack MAML2 gene rearrangements, recent studies have identified MAML2 fusion transcripts in recurrent GOCs, suggesting a link to aggressive behavior. The differential diagnosis includes both benign and malignant conditions. Treatment options range from conservative management to radical resection, with recurrence being a notable concern. This review highlights the need for accurate diagnosis and long-term follow-up, as no histopathological features reliably predict recurrence. Further research is needed to optimize treatment strategies and deepen understanding of its biological behavior.
eu_rights_str_mv openAccess
format article
id anni_65a2bac91afa2b8d84c96c8b7ce9bf36
identifier_str_mv Schuch, L, Silveira, F, González Umpiérrez, M, [y otros autores]. "Glandular odontogenic cyst: insights into a rare and challenging lesion". Journal of Oral Diagnosis. [en línea] 2025, 10:e292.
2525-5711
10.5327/2525-5711.292
instacron_str Universidad de la República
institution Universidad de la República
instname_str Universidad de la República
language eng
language_invalid_str_mv en_US
network_acronym_str anni
network_name_str oai-lr-anni
oai_identifier_str oai:colibri.udelar.edu.uy:20.500.12008/51892
publishDate 2025
publishDateSort 2025
publisher.none.fl_str_mv Brazilian Society of Oral Medicine and Oral Pathology (SOBEP).
reponame_str COLIBRI
repository.mail.fl_str_mv
repository.name.fl_str_mv
repository_id_str
rights_invalid_str_mv Licencia Creative Commons Atribución (CC - By 4.0)
spelling Glandular odontogenic cyst: insights into a rare and challenging lesion.Schuch, Lauren FrenzelSilveira, Felipe MartinsGonzález Umpiérrez, María NataliaBeovide Cortegoso, VerónicaSicco, EstefaníaBologna-Molina, RonellPereira-Prado, VanesaOdontogenic lesionGlandular odontogenic cystDiagnostic challengeQUISTES ODONTOGÉNICOSODONTOGENIC CYSTSThe glandular odontogenic cyst (GOC) is a rare developmental odontogenic cyst characterized by an epithelial lining resembling salivary or glandular tissue. Its aggressive behavior and potential for recurrence pose challenges in both diagnosis and management. This review consolidates current knowledge on etiopathogenesis, clinical presentation, histopathological features, and treatment approaches. GOC primarily affects male adults, often presenting asymptomatically, and is most commonly found in the mandible. Radiographically, it appears as a unilocular or multilocular radiolucency, frequently associated with unerupted teeth. Histologically, GOC is istinguished by a multilocular cystic structure lined with epithelial cells, which may include “hobnail,” clear, and mucous cells. While traditionally thought to lack MAML2 gene rearrangements, recent studies have identified MAML2 fusion transcripts in recurrent GOCs, suggesting a link to aggressive behavior. The differential diagnosis includes both benign and malignant conditions. Treatment options range from conservative management to radical resection, with recurrence being a notable concern. This review highlights the need for accurate diagnosis and long-term follow-up, as no histopathological features reliably predict recurrence. Further research is needed to optimize treatment strategies and deepen understanding of its biological behavior.Brazilian Society of Oral Medicine and Oral Pathology (SOBEP).Schuch Lauren Frenzel, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Silveira Felipe Martins, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.González Umpiérrez María Natalia, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Beovide Cortegoso Verónica, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Sicco Estefanía, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Bologna-Molina Ronell, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Pereira-Prado Vanesa, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.2025-10-03T17:54:37Z2025-10-03T17:54:37Z2025Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion6 h.application/pdfSchuch, L, Silveira, F, González Umpiérrez, M, [y otros autores]. "Glandular odontogenic cyst: insights into a rare and challenging lesion". Journal of Oral Diagnosis. [en línea] 2025, 10:e292.2525-5711https://hdl.handle.net/20.500.12008/5189210.5327/2525-5711.292reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la Repúblicaen_USengJournal of Oral Diagnosis, 2025, 10:e292.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)oai:colibri.udelar.edu.uy:20.500.12008/518922026-04-14T10:37:16Z
spellingShingle Glandular odontogenic cyst: insights into a rare and challenging lesion.
Schuch, Lauren Frenzel
Odontogenic lesion
Glandular odontogenic cyst
Diagnostic challenge
QUISTES ODONTOGÉNICOS
ODONTOGENIC CYSTS
status_str publishedVersion
title Glandular odontogenic cyst: insights into a rare and challenging lesion.
title_full Glandular odontogenic cyst: insights into a rare and challenging lesion.
title_fullStr Glandular odontogenic cyst: insights into a rare and challenging lesion.
title_full_unstemmed Glandular odontogenic cyst: insights into a rare and challenging lesion.
title_short Glandular odontogenic cyst: insights into a rare and challenging lesion.
title_sort Glandular odontogenic cyst: insights into a rare and challenging lesion.
topic Odontogenic lesion
Glandular odontogenic cyst
Diagnostic challenge
QUISTES ODONTOGÉNICOS
ODONTOGENIC CYSTS
url https://hdl.handle.net/20.500.12008/51892