Development of nitroalkene-based inhibitors to target STING-dependent inflammation
Información suplementaria en: https://doi.org/10.1016/j.redox.2024.103202
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| Other Authors: | , , , , , , , , , , , |
| Format: | article |
| Language: | English |
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2024
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| Online Access: | https://hdl.handle.net/20.500.12008/50451 |
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| _version_ | 1868890080538525696 |
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| author | Chang, Fei |
| author2 | Gunderstofte, Camila Colussi, Nicole Pitts, Mareena Salvatore, S.R. Thielke, Anne L. Turell Novo, Lucía Alvarez, Beatriz Goldbach-Mansky, Raphaela Villacorta, Luis Holm, Christian K. Schopfer, F.J. Hansen, Anne Louise |
| author2_role | author author author author author author author author author author author author |
| author_browse | Alvarez, Beatriz Chang, Fei Colussi, Nicole Goldbach-Mansky, Raphaela Gunderstofte, Camila Hansen, Anne Louise Holm, Christian K. Pitts, Mareena Salvatore, S.R. Schopfer, F.J. Thielke, Anne L. Turell Novo, Lucía Villacorta, Luis |
| author_facet | Chang, Fei Gunderstofte, Camila Colussi, Nicole Pitts, Mareena Salvatore, S.R. Thielke, Anne L. Turell Novo, Lucía Alvarez, Beatriz Goldbach-Mansky, Raphaela Villacorta, Luis Holm, Christian K. Schopfer, F.J. Hansen, Anne Louise |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Chang Fei Gunderstofte Camila Colussi Nicole Pitts Mareena Salvatore S.R. Thielke Anne L. Turell Novo Lucía Alvarez Beatriz, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. Goldbach-Mansky Raphaela Villacorta Luis Holm Christian K. Schopfer F.J. Hansen Anne Louise |
| dc.creator.none.fl_str_mv | Chang, Fei Gunderstofte, Camila Colussi, Nicole Pitts, Mareena Salvatore, S.R. Thielke, Anne L. Turell Novo, Lucía Alvarez, Beatriz Goldbach-Mansky, Raphaela Villacorta, Luis Holm, Christian K. Schopfer, F.J. Hansen, Anne Louise |
| dc.date.none.fl_str_mv | 2024 2025-07-02T16:41:56Z 2025-07-02T16:41:56Z |
| dc.format.none.fl_str_mv | 14 h application/pdf |
| dc.identifier.none.fl_str_mv | Chang, F, Gunderstofte, C, Colussi, N [y otros autores]. "Development of nitroalkene-based inhibitors to target STING-dependent inflammation". Redox Biology. [en línea] 2024, 74: 103202. 14 h. DOI: 10.1016/j.redox.2024.103202 2213-2317 https://hdl.handle.net/20.500.12008/50451 10.1016/j.redox.2024.103202 |
| dc.language.none.fl_str_mv | en eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.relation.none.fl_str_mv | Redox Biology, 2024, 74: 103202. |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Stimulator of Interferon Genes Drug discovery Nitroalkene-based compounds STING inhibitors STING-associated vasculopathy with onset in infancy Interferon |
| dc.title.none.fl_str_mv | Development of nitroalkene-based inhibitors to target STING-dependent inflammation |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Información suplementaria en: https://doi.org/10.1016/j.redox.2024.103202 |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_651cecf2a34cd0de2121c2c71a4d30f4 |
| identifier_str_mv | Chang, F, Gunderstofte, C, Colussi, N [y otros autores]. "Development of nitroalkene-based inhibitors to target STING-dependent inflammation". Redox Biology. [en línea] 2024, 74: 103202. 14 h. DOI: 10.1016/j.redox.2024.103202 2213-2317 10.1016/j.redox.2024.103202 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/50451 |
| publishDate | 2024 |
| publishDateSort | 2024 |
| publisher.none.fl_str_mv | Elsevier |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| spelling | Development of nitroalkene-based inhibitors to target STING-dependent inflammationChang, FeiGunderstofte, CamilaColussi, NicolePitts, MareenaSalvatore, S.R.Thielke, Anne L.Turell Novo, LucíaAlvarez, BeatrizGoldbach-Mansky, RaphaelaVillacorta, LuisHolm, Christian K.Schopfer, F.J.Hansen, Anne LouiseStimulator of Interferon GenesDrug discovery Nitroalkene-based compoundsSTING inhibitorsSTING-associated vasculopathy with onset in infancyInterferonInformación suplementaria en: https://doi.org/10.1016/j.redox.2024.103202Stimulator of Interferon Genes (STING) is essential for the inflammatory response to cytosolic DNA. Despite that aberrant activation of STING is linked to an increasing number of inflammatory diseases, the development of inhibitors has been challenging, with no compounds in the pipeline beyond the preclinical stage. We previously identified endogenous nitrated fatty acids as novel reversible STING inhibitors. With the aim of improving the specificity and efficacy of these compounds, we developed and tested a library of nitroalkene-based compounds for in vitro and in vivo STING inhibition. The structure-activity relationship study revealed a robustly improved electrophilicity and reduced degrees of freedom of nitroalkenes by conjugation with an aromatic moiety. The lead compounds CP-36 and CP-45, featuring a β-nitrostyrene moiety, potently inhibited STING activity in vitro and relieved STING-dependent inflammation in vivo. This validates the potential for nitroalkene compounds as drug candidates for STING modulation to treat STING-driven inflammatory diseases, providing new robust leads for preclinical development.ElsevierChang FeiGunderstofte CamilaColussi NicolePitts MareenaSalvatore S.R.Thielke Anne L.Turell Novo LucíaAlvarez Beatriz, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica.Goldbach-Mansky RaphaelaVillacorta LuisHolm Christian K.Schopfer F.J.Hansen Anne Louise2025-07-02T16:41:56Z2025-07-02T16:41:56Z2024Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion14 happlication/pdfChang, F, Gunderstofte, C, Colussi, N [y otros autores]. "Development of nitroalkene-based inhibitors to target STING-dependent inflammation". Redox Biology. [en línea] 2024, 74: 103202. 14 h. DOI: 10.1016/j.redox.2024.1032022213-2317https://hdl.handle.net/20.500.12008/5045110.1016/j.redox.2024.103202reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengRedox Biology, 2024, 74: 103202.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)oai:colibri.udelar.edu.uy:20.500.12008/504512026-04-14T10:10:52Z |
| spellingShingle | Development of nitroalkene-based inhibitors to target STING-dependent inflammation Chang, Fei Stimulator of Interferon Genes Drug discovery Nitroalkene-based compounds STING inhibitors STING-associated vasculopathy with onset in infancy Interferon |
| status_str | publishedVersion |
| title | Development of nitroalkene-based inhibitors to target STING-dependent inflammation |
| title_full | Development of nitroalkene-based inhibitors to target STING-dependent inflammation |
| title_fullStr | Development of nitroalkene-based inhibitors to target STING-dependent inflammation |
| title_full_unstemmed | Development of nitroalkene-based inhibitors to target STING-dependent inflammation |
| title_short | Development of nitroalkene-based inhibitors to target STING-dependent inflammation |
| title_sort | Development of nitroalkene-based inhibitors to target STING-dependent inflammation |
| topic | Stimulator of Interferon Genes Drug discovery Nitroalkene-based compounds STING inhibitors STING-associated vasculopathy with onset in infancy Interferon |
| url | https://hdl.handle.net/20.500.12008/50451 |