Proliferation, angiogenesis and differentiation related markers in compact and follicular-compact thyroid carcinomas in dogs
Immunohistochemical markers (IGF-1, IGF-1R, VEGF, FGF-2, RARα and RXR) were evaluated in healthy canine thyroid glands (n=8) and in follicular-compact (n=8) and compact thyroid carcinomas (n=8). IGF-1, IGF-1R and VEGF expression was higher in fibroblasts and endothelial cells of compact carcinoma th...
Enregistré dans:
| Auteur principal: | |
|---|---|
| Autres auteurs: | , , , |
| Format: | article |
| Langue: | anglais |
| Publié: |
2016
|
| Sujets: | |
| Accès en ligne: | https://hdl.handle.net/20.500.12008/50637 http://dx.doi.org/10.4314/ovj.v6i3.15 |
| Tags: |
Pas de tags, Soyez le premier à ajouter un tag!
|
| Résumé: | Immunohistochemical markers (IGF-1, IGF-1R, VEGF, FGF-2, RARα and RXR) were evaluated in healthy canine thyroid glands (n=8) and in follicular-compact (n=8) and compact thyroid carcinomas (n=8). IGF-1, IGF-1R and VEGF expression was higher in fibroblasts and endothelial cells of compact carcinoma than in healthy glands (P < 0.05). Compared to follicular-compact carcinoma, compact carcinoma had higher IGF-1R expression in fibroblasts, and higher FGF-2 expression in endothelial cells (P < 0.05). RARα expression was higher in endothelial cells of compact carcinoma than in those of other groups (P < 0.05). The upregulation of these proliferation- and angiogenesis-related factors in endothelial cells and/or fibroblasts and not in follicular cells of compact carcinoma compared to healthy glands supports the relevance of stromal cells in cancer progression. |
|---|