Inter- and intracontinental migrations and local differentiation have shaped the contemporary epidemiological landscape of canine parvovirus in South America
Canine parvovirus (CPV) is a fast-evolving single-stranded DNA virus that causes one of the most significant infectious diseases of dogs. Although the virus dispersed over long distances in the past, current populations are considered to be spatially confined and with only a few instances of migrati...
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| Formatua: | article |
| Hizkuntza: | ingelesa |
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2018
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| Sarrera elektronikoa: | https://hdl.handle.net/20.500.12008/22060 |
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Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!
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| _version_ | 1868890073462734848 |
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| author | Grecco Patiño, Sofía |
| author2 | Iraola, Gregorio Decaro, N. Alfieri, A. Gallo Calderón, M. Da Silva, A. P. Name, Daniela Aldaz, Jaime Calleros Basilio, Lucía Marandino, Ana Tomás Custodio, Gonzalo Martín Maya Soto, Leticia María Francia, Lourdes Panzera Crespo, Yanina Pérez Crossa, Ruben Gustavo |
| author2_role | author author author author author author author author author author author author author author |
| author_browse | Aldaz, Jaime Alfieri, A. Calleros Basilio, Lucía Da Silva, A. P. Decaro, N. Francia, Lourdes Gallo Calderón, M. Grecco Patiño, Sofía Iraola, Gregorio Marandino, Ana Maya Soto, Leticia María Name, Daniela Panzera Crespo, Yanina Pérez Crossa, Ruben Gustavo Tomás Custodio, Gonzalo Martín |
| author_facet | Grecco Patiño, Sofía Iraola, Gregorio Decaro, N. Alfieri, A. Gallo Calderón, M. Da Silva, A. P. Name, Daniela Aldaz, Jaime Calleros Basilio, Lucía Marandino, Ana Tomás Custodio, Gonzalo Martín Maya Soto, Leticia María Francia, Lourdes Panzera Crespo, Yanina Pérez Crossa, Ruben Gustavo |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Grecco Patiño, Sofía. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología Iraola, Gregorio. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología Name, Daniela. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología Calleros Basilio, Lucía. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología Marandino, Ana. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología Tomás, Gonzalo. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología Maya Soto Leticia María. Universidad de la República. Facultad de Ciencias. Instituto de Biología Francia, Lourdes. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología Panzera Crespo, Yanina . Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología Pérez Crossa, Ruben Gustavo. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología |
| dc.creator.none.fl_str_mv | Grecco Patiño, Sofía Iraola, Gregorio Decaro, N. Alfieri, A. Gallo Calderón, M. Da Silva, A. P. Name, Daniela Aldaz, Jaime Calleros Basilio, Lucía Marandino, Ana Tomás Custodio, Gonzalo Martín Maya Soto, Leticia María Francia, Lourdes Panzera Crespo, Yanina Pérez Crossa, Ruben Gustavo |
| dc.date.none.fl_str_mv | 2018 2019-10-02T22:12:07Z 2019-10-02T22:12:07Z 20190930 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Grecco, S., et al. Inter- and intracontinental migrations and local differentiation have shaped the contemporary epidemiological landscape of canine parvovirus in South America. Virus Evolution, 2018, 4 (1), vey011. doi: 10.1093/ve/vey011 2057-1577 https://hdl.handle.net/20.500.12008/22060 10.1093/ve/vey011 |
| dc.language.none.fl_str_mv | en eng |
| dc.publisher.none.fl_str_mv | Oxford University Press |
| dc.relation.none.fl_str_mv | Virus Evolution, 2018, 4 (1), vey011 |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución – No Comercial (CC-BY-NC- 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Canine parvovirus Genomic evolution South America Phylodynamics |
| dc.title.none.fl_str_mv | Inter- and intracontinental migrations and local differentiation have shaped the contemporary epidemiological landscape of canine parvovirus in South America |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Canine parvovirus (CPV) is a fast-evolving single-stranded DNA virus that causes one of the most significant infectious diseases of dogs. Although the virus dispersed over long distances in the past, current populations are considered to be spatially confined and with only a few instances of migration between specific localities. It is unclear whether these dynamics occur in South America where global studies have not been performed. The aim of this study is to analyze the patterns of genetic variability in South American CPV populations and explore their evolutionary relationships with global strains. Genomic sequences of sixty-three strains from South America and Europe were generated and analyzed using a phylodynamic approach. All the obtained strains belong to the CPV-2a lineage and associate with global strains in four monophyletic groups or clades. European and South American strains from all the countries here analyzed are representative of a widely distributed clade (Eur-I) that emerged in Southern Europe during 1990–98 to later spread to South America in the early 2000s. The emergence and spread of the Eur-I clade were correlated with a significant rise in the CPV effective population size in Europe and South America. The Asia-I clade includes strains from Asia and Uruguay. This clade originated in Asia during the late 1980s and evolved locally before spreading to South America during 2009–10. The third clade (Eur-II) comprises strains from Italy, Brazil, and Ecuador. This clade appears in South America as a consequence of an early introduction from Italy to Ecuador in the middle 1980s and has experienced extensive local genetic differentiation. Some strains from Argentina, Uruguay, and Brazil constitute an exclusive South American clade (SA-I) that emerged in Argentina in the 1990s. These results indicate that the current epidemiological scenario is a consequence of inter- and intracontinental migrations of strains with different geographic and temporal origins that set the conditions for competition and local differentiation of CPV populations. The coexistence and interaction of highly divergent strains are the main responsible for the drastic epidemiological changes observed in South America in the last two decades. This highlights the threat of invasion from external sources and the importance of whole-genome resolution to robustly infer the origin and spread of new CPV variants. From a taxonomic standpoint, the findings herein show that the classification system that uses a single amino acid to identify variants (2a, 2b, and 2c) within the CPV-2a lineage does not reflect phylogenetic relationships and is not suitable to analyze CPV evolution. In this regard, the identification of clades or sublineages within circulating CPV strains is the first step towards a genetic and evolutionary classification of the virus. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_5d77eeb9bef425ea2203bbb2b1bbee99 |
| identifier_str_mv | Grecco, S., et al. Inter- and intracontinental migrations and local differentiation have shaped the contemporary epidemiological landscape of canine parvovirus in South America. Virus Evolution, 2018, 4 (1), vey011. doi: 10.1093/ve/vey011 2057-1577 10.1093/ve/vey011 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/22060 |
| publishDate | 2018 |
| publishDateSort | 2018 |
| publisher.none.fl_str_mv | Oxford University Press |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución – No Comercial (CC-BY-NC- 4.0) |
| spelling | Inter- and intracontinental migrations and local differentiation have shaped the contemporary epidemiological landscape of canine parvovirus in South AmericaGrecco Patiño, SofíaIraola, GregorioDecaro, N.Alfieri, A.Gallo Calderón, M.Da Silva, A. P.Name, DanielaAldaz, JaimeCalleros Basilio, LucíaMarandino, AnaTomás Custodio, Gonzalo MartínMaya Soto, Leticia MaríaFrancia, LourdesPanzera Crespo, YaninaPérez Crossa, Ruben GustavoCanine parvovirusGenomic evolutionSouth AmericaPhylodynamicsCanine parvovirus (CPV) is a fast-evolving single-stranded DNA virus that causes one of the most significant infectious diseases of dogs. Although the virus dispersed over long distances in the past, current populations are considered to be spatially confined and with only a few instances of migration between specific localities. It is unclear whether these dynamics occur in South America where global studies have not been performed. The aim of this study is to analyze the patterns of genetic variability in South American CPV populations and explore their evolutionary relationships with global strains. Genomic sequences of sixty-three strains from South America and Europe were generated and analyzed using a phylodynamic approach. All the obtained strains belong to the CPV-2a lineage and associate with global strains in four monophyletic groups or clades. European and South American strains from all the countries here analyzed are representative of a widely distributed clade (Eur-I) that emerged in Southern Europe during 1990–98 to later spread to South America in the early 2000s. The emergence and spread of the Eur-I clade were correlated with a significant rise in the CPV effective population size in Europe and South America. The Asia-I clade includes strains from Asia and Uruguay. This clade originated in Asia during the late 1980s and evolved locally before spreading to South America during 2009–10. The third clade (Eur-II) comprises strains from Italy, Brazil, and Ecuador. This clade appears in South America as a consequence of an early introduction from Italy to Ecuador in the middle 1980s and has experienced extensive local genetic differentiation. Some strains from Argentina, Uruguay, and Brazil constitute an exclusive South American clade (SA-I) that emerged in Argentina in the 1990s. These results indicate that the current epidemiological scenario is a consequence of inter- and intracontinental migrations of strains with different geographic and temporal origins that set the conditions for competition and local differentiation of CPV populations. The coexistence and interaction of highly divergent strains are the main responsible for the drastic epidemiological changes observed in South America in the last two decades. This highlights the threat of invasion from external sources and the importance of whole-genome resolution to robustly infer the origin and spread of new CPV variants. From a taxonomic standpoint, the findings herein show that the classification system that uses a single amino acid to identify variants (2a, 2b, and 2c) within the CPV-2a lineage does not reflect phylogenetic relationships and is not suitable to analyze CPV evolution. In this regard, the identification of clades or sublineages within circulating CPV strains is the first step towards a genetic and evolutionary classification of the virus.Oxford University PressGrecco Patiño, Sofía. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de BiologíaIraola, Gregorio. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de BiologíaName, Daniela. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de BiologíaCalleros Basilio, Lucía. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de BiologíaMarandino, Ana. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de BiologíaTomás, Gonzalo. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de BiologíaMaya Soto Leticia María. Universidad de la República. Facultad de Ciencias. Instituto de BiologíaFrancia, Lourdes. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de BiologíaPanzera Crespo, Yanina . Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de BiologíaPérez Crossa, Ruben Gustavo. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología2019-10-02T22:12:07Z2019-10-02T22:12:07Z201820190930Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfGrecco, S., et al. Inter- and intracontinental migrations and local differentiation have shaped the contemporary epidemiological landscape of canine parvovirus in South America. Virus Evolution, 2018, 4 (1), vey011. doi: 10.1093/ve/vey0112057-1577https://hdl.handle.net/20.500.12008/2206010.1093/ve/vey011reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengVirus Evolution, 2018, 4 (1), vey011Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad De La República. (Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución – No Comercial (CC-BY-NC- 4.0)oai:colibri.udelar.edu.uy:20.500.12008/220602026-04-14T10:09:18Z |
| spellingShingle | Inter- and intracontinental migrations and local differentiation have shaped the contemporary epidemiological landscape of canine parvovirus in South America Grecco Patiño, Sofía Canine parvovirus Genomic evolution South America Phylodynamics |
| status_str | publishedVersion |
| title | Inter- and intracontinental migrations and local differentiation have shaped the contemporary epidemiological landscape of canine parvovirus in South America |
| title_full | Inter- and intracontinental migrations and local differentiation have shaped the contemporary epidemiological landscape of canine parvovirus in South America |
| title_fullStr | Inter- and intracontinental migrations and local differentiation have shaped the contemporary epidemiological landscape of canine parvovirus in South America |
| title_full_unstemmed | Inter- and intracontinental migrations and local differentiation have shaped the contemporary epidemiological landscape of canine parvovirus in South America |
| title_short | Inter- and intracontinental migrations and local differentiation have shaped the contemporary epidemiological landscape of canine parvovirus in South America |
| title_sort | Inter- and intracontinental migrations and local differentiation have shaped the contemporary epidemiological landscape of canine parvovirus in South America |
| topic | Canine parvovirus Genomic evolution South America Phylodynamics |
| url | https://hdl.handle.net/20.500.12008/22060 |