Expression of parathyroid hormone related protein (PTHRP) in ameloblastomas
Background: Presence of parathyroid hormone related protein (PTHrP) might suggest that ameloblastomas recapitulate features of the enamel epithelium and induce bone resorption, which would facilitate their growth and local invasion. The aim of this study was to determine the expression of PTHrP in a...
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| Format: | article |
| Idioma: | anglès |
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2018
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| Accés en línia: | http://hdl.handle.net/20.500.12008/18469 |
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| _version_ | 1868890054053593088 |
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| author | Zeballos, R. |
| author2 | Bologna-Molina, Ronell Pereira-Prado, Vanesa Villarroel-Dorrego, Mariana |
| author2_role | author author author |
| author_browse | Bologna-Molina, Ronell Pereira-Prado, Vanesa Villarroel-Dorrego, Mariana Zeballos, R. |
| author_facet | Zeballos, R. Bologna-Molina, Ronell Pereira-Prado, Vanesa Villarroel-Dorrego, Mariana |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Zeballos R., Hospital General del Oeste, Caracas, Venezuela Bologna-Molina Ronell, Universidad de la República (Uruguay). Facultad de Odontología Pereira-Prado Vanesa, Universidad de la República (Uruguay). Facultad de Odontología Villarroel-Dorrego Mariana., Universidad Central de Venezuela |
| dc.creator.none.fl_str_mv | Zeballos, R. Bologna-Molina, Ronell Pereira-Prado, Vanesa Villarroel-Dorrego, Mariana |
| dc.date.none.fl_str_mv | 2018-10-05T18:23:16Z 2018-10-05T18:23:16Z 2018 |
| dc.format.none.fl_str_mv | 5 h. application/pdf |
| dc.identifier.none.fl_str_mv | Zeballos, R, Bologna-Molina, R, Pereira-Prado, V y Villarroel-Dorrego, M. "Expression of parathyroid hormone related protein (PTHRP) in ameloblastomas" [en línea] Journal of clinical and experimental dentistry, 2018 (10) 2: e172-e176. 1989-5488 doi:10.4317/jced.54222 http://hdl.handle.net/20.500.12008/18469 |
| dc.language.none.fl_str_mv | en eng |
| dc.relation.none.fl_str_mv | Journal of clinical and experimental dentistry, 2018 (10) 2: e172-e176 |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Proteína relacionada con la hormona paratiroidea PTHrP Hueso Parathyroid hormone related protein Bone AMELOBLASTOMA |
| dc.title.none.fl_str_mv | Expression of parathyroid hormone related protein (PTHRP) in ameloblastomas |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Background: Presence of parathyroid hormone related protein (PTHrP) might suggest that ameloblastomas recapitulate features of the enamel epithelium and induce bone resorption, which would facilitate their growth and local invasion. The aim of this study was to determine the expression of PTHrP in ameloblastomas. Material and Methods: An observational research study was designed including 39 cases of histologically diagnosed ameloblastomas (39 out of 42 patients gave consent for the use of their medical records and all data required for this study). Gender, age, tumor location, histological type and subtype of the tumor were recorded and PTHrP expression was determined by indirect immunohistochemistry using monoclonal anti-human PTHrP (1D1 / Santa Cruz Biotechnology). Protein expression and intensity were evaluated under light microscope and finally data recorded and statistically analyzed. This research was approved by the Caracas West General Hospital review board. Results: 39 cases of ameloblastomas were evenly distributed between genders (49% male and 51% female) with a mean age of 33 ± 3.53 years, mainly affecting the posterior mandible. 20 cases (51.28%) showed positive cytoplasmic immunoreactivity to PTHrP. 8 out of 15 cases of solid/multicystic ameloblastomas and 12 out of 23 cases of unicystic ameloblastomas were PTHrP positive. Intense expression of PTHrP was observed in 4 unicystic ameloblastomas (all luminal subtype) and in 5 cases of conventional ameloblastomas. Conclusions: In the present study PTHrP expression in solid multicystic and unicystic ameloblastoma suggests its possible function in the biological behavior of the tumor. More studies are needed in order to determine the possible role of this protein related to bone invasion processes. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_529a02ccb68f162e0e8ec0c8860ec5fb |
| identifier_str_mv | Zeballos, R, Bologna-Molina, R, Pereira-Prado, V y Villarroel-Dorrego, M. "Expression of parathyroid hormone related protein (PTHRP) in ameloblastomas" [en línea] Journal of clinical and experimental dentistry, 2018 (10) 2: e172-e176. 1989-5488 doi:10.4317/jced.54222 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/18469 |
| publishDate | 2018 |
| publishDateSort | 2018 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Expression of parathyroid hormone related protein (PTHRP) in ameloblastomasZeballos, R.Bologna-Molina, RonellPereira-Prado, VanesaVillarroel-Dorrego, MarianaProteína relacionada con la hormona paratiroideaPTHrPHuesoParathyroid hormone related proteinBoneAMELOBLASTOMABackground: Presence of parathyroid hormone related protein (PTHrP) might suggest that ameloblastomas recapitulate features of the enamel epithelium and induce bone resorption, which would facilitate their growth and local invasion. The aim of this study was to determine the expression of PTHrP in ameloblastomas. Material and Methods: An observational research study was designed including 39 cases of histologically diagnosed ameloblastomas (39 out of 42 patients gave consent for the use of their medical records and all data required for this study). Gender, age, tumor location, histological type and subtype of the tumor were recorded and PTHrP expression was determined by indirect immunohistochemistry using monoclonal anti-human PTHrP (1D1 / Santa Cruz Biotechnology). Protein expression and intensity were evaluated under light microscope and finally data recorded and statistically analyzed. This research was approved by the Caracas West General Hospital review board. Results: 39 cases of ameloblastomas were evenly distributed between genders (49% male and 51% female) with a mean age of 33 ± 3.53 years, mainly affecting the posterior mandible. 20 cases (51.28%) showed positive cytoplasmic immunoreactivity to PTHrP. 8 out of 15 cases of solid/multicystic ameloblastomas and 12 out of 23 cases of unicystic ameloblastomas were PTHrP positive. Intense expression of PTHrP was observed in 4 unicystic ameloblastomas (all luminal subtype) and in 5 cases of conventional ameloblastomas. Conclusions: In the present study PTHrP expression in solid multicystic and unicystic ameloblastoma suggests its possible function in the biological behavior of the tumor. More studies are needed in order to determine the possible role of this protein related to bone invasion processes.Zeballos R., Hospital General del Oeste, Caracas, VenezuelaBologna-Molina Ronell, Universidad de la República (Uruguay). Facultad de OdontologíaPereira-Prado Vanesa, Universidad de la República (Uruguay). Facultad de OdontologíaVillarroel-Dorrego Mariana., Universidad Central de Venezuela2018-10-05T18:23:16Z2018-10-05T18:23:16Z2018Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion5 h.application/pdfZeballos, R, Bologna-Molina, R, Pereira-Prado, V y Villarroel-Dorrego, M. "Expression of parathyroid hormone related protein (PTHRP) in ameloblastomas" [en línea] Journal of clinical and experimental dentistry, 2018 (10) 2: e172-e176.1989-5488doi:10.4317/jced.54222http://hdl.handle.net/20.500.12008/18469reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengJournal of clinical and experimental dentistry, 2018 (10) 2: e172-e176Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessoai:colibri.udelar.edu.uy:20.500.12008/184692026-04-14T10:16:30Z |
| spellingShingle | Expression of parathyroid hormone related protein (PTHRP) in ameloblastomas Zeballos, R. Proteína relacionada con la hormona paratiroidea PTHrP Hueso Parathyroid hormone related protein Bone AMELOBLASTOMA |
| status_str | publishedVersion |
| title | Expression of parathyroid hormone related protein (PTHRP) in ameloblastomas |
| title_full | Expression of parathyroid hormone related protein (PTHRP) in ameloblastomas |
| title_fullStr | Expression of parathyroid hormone related protein (PTHRP) in ameloblastomas |
| title_full_unstemmed | Expression of parathyroid hormone related protein (PTHRP) in ameloblastomas |
| title_short | Expression of parathyroid hormone related protein (PTHRP) in ameloblastomas |
| title_sort | Expression of parathyroid hormone related protein (PTHRP) in ameloblastomas |
| topic | Proteína relacionada con la hormona paratiroidea PTHrP Hueso Parathyroid hormone related protein Bone AMELOBLASTOMA |
| url | http://hdl.handle.net/20.500.12008/18469 |