piRNA pathway evolution beyond gonad context: Perspectives from apicomplexa and trypanosomatids
piRNAs function as genome defense mechanisms against transposable elements insertions within germ line cells. Recent studies have unraveled that piRNA pathways are not limited to germ cells as initially reckoned, but are instead also found in non-gonadal somatic contexts. Moreover, these pathways ha...
Uloženo v:
| Hlavní autor: | |
|---|---|
| Další autoři: | , , , |
| Médium: | article |
| Jazyk: | angličtina |
| Vydáno: |
2023
|
| Témata: | |
| On-line přístup: | https://hdl.handle.net/20.500.12008/52746 |
| Tagy: |
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| _version_ | 1868890050798813184 |
|---|---|
| author | Horjales, Sofía |
| author2 | Li Calzi, Marco Francia, María E. Cayota, Alfonso Garcia-Silva, María Rosa |
| author2_role | author author author author |
| author_browse | Cayota, Alfonso Francia, María E. Garcia-Silva, María Rosa Horjales, Sofía Li Calzi, Marco |
| author_facet | Horjales, Sofía Li Calzi, Marco Francia, María E. Cayota, Alfonso Garcia-Silva, María Rosa |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Horjales Sofía, Institute Pasteur Montevideo (Uruguay) Li Calzi Marco, Institute Pasteur Montevideo (Uruguay) Francia María E., Universidad de la República (Uruguay). Facultad de Medicina Cayota Alfonso, Universidad de la República (Uruguay). Facultad de Medicina Garcia-Silva María Rosa, Institute Pasteur Montevideo (Uruguay) |
| dc.creator.none.fl_str_mv | Horjales, Sofía Li Calzi, Marco Francia, María E. Cayota, Alfonso Garcia-Silva, María Rosa |
| dc.date.none.fl_str_mv | 2023 2025-12-01T21:19:43Z 2025-12-01T21:19:43Z |
| dc.format.none.fl_str_mv | 7 p. application/pdf |
| dc.identifier.none.fl_str_mv | Horjales S, Li Calzi M, Francia M y otros. piRNA pathway evolution beyond gonad context: Perspectives from apicomplexa and trypanosomatids[en línea]. Frontiers in Genetics. 2023;14 [en línea]. 7 p. 1664-8021 https://hdl.handle.net/20.500.12008/52746 10.3389/fgene.2023.1129194 |
| dc.language.none.fl_str_mv | en eng |
| dc.publisher.none.fl_str_mv | Frontiers |
| dc.relation.none.fl_str_mv | Frontiers in Genetics. 2023;14 |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Argonautes (AGO) PIWI Toxoplasma Trypanosoma piRNA biogenesis ARN DE INTERACCIÓN CON PIWI TRYPANOSOMA TOXOPLASMA TOXOPLASMOSIS APICOMPLEXA PROTEÍNAS ARGONAUTAS |
| dc.title.none.fl_str_mv | piRNA pathway evolution beyond gonad context: Perspectives from apicomplexa and trypanosomatids |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | piRNAs function as genome defense mechanisms against transposable elements insertions within germ line cells. Recent studies have unraveled that piRNA pathways are not limited to germ cells as initially reckoned, but are instead also found in non-gonadal somatic contexts. Moreover, these pathways have also been reported in bacteria, mollusks and arthropods, associated with safeguard of genomes against transposable elements, regulation of gene expression and with direct consequences in axon regeneration and memory formation. In this Perspective we draw attention to early branching parasitic protozoa, whose genome preservation is an essential function as in late eukaryotes. However, little is known about the defense mechanisms of these genomes. We and others have described the presence of putative PIWI-related machinery members in protozoan parasites. We have described the presence of a PIWI-like protein in Trypanosoma cruzi, bound to small non-coding RNAs (sRNAs) as cargo of secreted extracellular vesicles relevant in intercellular communication and host infection. Herein, we put forward the presence of members related to Argonaute pathways in both Trypanosoma cruzi and Toxoplasma gondii. The presence of PIWI-like machinery in Trypansomatids and Apicomplexa, respectively, could be evidence of an ancestral piRNA machinery that evolved to become more sophisticated and complex in multicellular eukaryotes. We propose a model in which ancient PIWI proteins were expressed broadly and had functions independent of germline maintenance. A better understanding of current and ancestral PIWI/piRNAs will be relevant to better understand key mechanisms of genome integrity conservation during cell cycle progression and modulation of host defense mechanisms by protozoan parasites. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_5104f8d650d873c61cf23ac2120e33b7 |
| identifier_str_mv | Horjales S, Li Calzi M, Francia M y otros. piRNA pathway evolution beyond gonad context: Perspectives from apicomplexa and trypanosomatids[en línea]. Frontiers in Genetics. 2023;14 [en línea]. 7 p. 1664-8021 10.3389/fgene.2023.1129194 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/52746 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| publisher.none.fl_str_mv | Frontiers |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | piRNA pathway evolution beyond gonad context: Perspectives from apicomplexa and trypanosomatidsHorjales, SofíaLi Calzi, MarcoFrancia, María E.Cayota, AlfonsoGarcia-Silva, María RosaArgonautes (AGO)PIWIToxoplasmaTrypanosomapiRNA biogenesisARN DE INTERACCIÓN CON PIWITRYPANOSOMATOXOPLASMATOXOPLASMOSISAPICOMPLEXAPROTEÍNAS ARGONAUTASpiRNAs function as genome defense mechanisms against transposable elements insertions within germ line cells. Recent studies have unraveled that piRNA pathways are not limited to germ cells as initially reckoned, but are instead also found in non-gonadal somatic contexts. Moreover, these pathways have also been reported in bacteria, mollusks and arthropods, associated with safeguard of genomes against transposable elements, regulation of gene expression and with direct consequences in axon regeneration and memory formation. In this Perspective we draw attention to early branching parasitic protozoa, whose genome preservation is an essential function as in late eukaryotes. However, little is known about the defense mechanisms of these genomes. We and others have described the presence of putative PIWI-related machinery members in protozoan parasites. We have described the presence of a PIWI-like protein in Trypanosoma cruzi, bound to small non-coding RNAs (sRNAs) as cargo of secreted extracellular vesicles relevant in intercellular communication and host infection. Herein, we put forward the presence of members related to Argonaute pathways in both Trypanosoma cruzi and Toxoplasma gondii. The presence of PIWI-like machinery in Trypansomatids and Apicomplexa, respectively, could be evidence of an ancestral piRNA machinery that evolved to become more sophisticated and complex in multicellular eukaryotes. We propose a model in which ancient PIWI proteins were expressed broadly and had functions independent of germline maintenance. A better understanding of current and ancestral PIWI/piRNAs will be relevant to better understand key mechanisms of genome integrity conservation during cell cycle progression and modulation of host defense mechanisms by protozoan parasites.FrontiersHorjales Sofía, Institute Pasteur Montevideo (Uruguay)Li Calzi Marco, Institute Pasteur Montevideo (Uruguay)Francia María E., Universidad de la República (Uruguay). Facultad de MedicinaCayota Alfonso, Universidad de la República (Uruguay). Facultad de MedicinaGarcia-Silva María Rosa, Institute Pasteur Montevideo (Uruguay)2025-12-01T21:19:43Z2025-12-01T21:19:43Z2023Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion7 p.application/pdfHorjales S, Li Calzi M, Francia M y otros. piRNA pathway evolution beyond gonad context: Perspectives from apicomplexa and trypanosomatids[en línea]. Frontiers in Genetics. 2023;14 [en línea]. 7 p.1664-8021https://hdl.handle.net/20.500.12008/5274610.3389/fgene.2023.1129194reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengFrontiers in Genetics. 2023;14Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)oai:colibri.udelar.edu.uy:20.500.12008/527462026-04-14T10:28:23Z |
| spellingShingle | piRNA pathway evolution beyond gonad context: Perspectives from apicomplexa and trypanosomatids Horjales, Sofía Argonautes (AGO) PIWI Toxoplasma Trypanosoma piRNA biogenesis ARN DE INTERACCIÓN CON PIWI TRYPANOSOMA TOXOPLASMA TOXOPLASMOSIS APICOMPLEXA PROTEÍNAS ARGONAUTAS |
| status_str | publishedVersion |
| title | piRNA pathway evolution beyond gonad context: Perspectives from apicomplexa and trypanosomatids |
| title_full | piRNA pathway evolution beyond gonad context: Perspectives from apicomplexa and trypanosomatids |
| title_fullStr | piRNA pathway evolution beyond gonad context: Perspectives from apicomplexa and trypanosomatids |
| title_full_unstemmed | piRNA pathway evolution beyond gonad context: Perspectives from apicomplexa and trypanosomatids |
| title_short | piRNA pathway evolution beyond gonad context: Perspectives from apicomplexa and trypanosomatids |
| title_sort | piRNA pathway evolution beyond gonad context: Perspectives from apicomplexa and trypanosomatids |
| topic | Argonautes (AGO) PIWI Toxoplasma Trypanosoma piRNA biogenesis ARN DE INTERACCIÓN CON PIWI TRYPANOSOMA TOXOPLASMA TOXOPLASMOSIS APICOMPLEXA PROTEÍNAS ARGONAUTAS |
| url | https://hdl.handle.net/20.500.12008/52746 |