Salmonella-Induced Cell Death in Cancer Immunotherapy: What Lies Beneath?
Bacteria-based cancer immunotherapies are regaining attention due to recent advances in understanding the mechanisms underlying their efficacy, making them promising tools for cancer treatment. Among these, Salmonella stands out as one of the most extensively studied microorganisms in this field. It...
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| Kolejni autorzy: | , , , |
| Format: | article |
| Język: | angielski |
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2026
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| Hasła przedmiotowe: | |
| Dostęp online: | https://hdl.handle.net/20.500.12008/53273 |
| Etykiety: |
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| _version_ | 1868890043996700672 |
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| author | Mónaco, Amy |
| author2 | Chilibroste, Sofía Plata, María Clara Chabalgoity, Jose Alejandro Moreno, María |
| author2_role | author author author author |
| author_browse | Chabalgoity, Jose Alejandro Chilibroste, Sofía Moreno, María Mónaco, Amy Plata, María Clara |
| author_facet | Mónaco, Amy Chilibroste, Sofía Plata, María Clara Chabalgoity, Jose Alejandro Moreno, María |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Mónaco Amy, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Desarrollo Biotecnológico Chilibroste Sofía, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Desarrollo Biotecnológico Plata María Clara, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Desarrollo Biotecnológico Chabalgoity Jose Alejandro, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Desarrollo Biotecnológico Moreno María, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Desarrollo Biotecnológico |
| dc.creator.none.fl_str_mv | Mónaco, Amy Chilibroste, Sofía Plata, María Clara Chabalgoity, Jose Alejandro Moreno, María |
| dc.date.none.fl_str_mv | 2026-01-20T18:10:02Z 2026-01-20T18:10:02Z 2026 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | MÓNACO, A., CHILIBROSTE, S., PLATA, MA., y otros. Salmonella-Induced Cell Death in Cancer Immunotherapy: What Lies Beneath?. Biomedicines [en línea] 2026, 14. DOI: 10.3390/biomedicines14010012 https://hdl.handle.net/20.500.12008/53273 10.3390/biomedicines14010012 |
| dc.language.none.fl_str_mv | en eng |
| dc.relation.none.fl_str_mv | Biomedicines.14, 2026 |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Salmonella Cancer immunotherapy Cell death Apoptosis Pyroptosis Autophagy |
| dc.title.none.fl_str_mv | Salmonella-Induced Cell Death in Cancer Immunotherapy: What Lies Beneath? |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Bacteria-based cancer immunotherapies are regaining attention due to recent advances in understanding the mechanisms underlying their efficacy, making them promising tools for cancer treatment. Among these, Salmonella stands out as one of the most extensively studied microorganisms in this field. Its ability to directly induce tumor cell death while stimulating the immune system offers unique therapeutic advantages, as cell death within an inflamma- tory environment may enhance the release of tumor antigens and promote effective antitu- mor immune responses. Although multiple studies have addressed Salmonella-induced cell death, the nomenclature and classification of death modalities are often inconsistent—either because earlier reports predate the formalization of certain death pathways, or due to over- lapping criteria between different types of cell death. This review aims to comprehensively analyze the available evidence on Salmonella-induced apoptosis, pyroptosis and autophagy, as well as other less characterized death modalities. Given that most mechanistics evidence on Salmonella-induced cell death has been generated in myeloid cells, we primarily focus on the myeloid compartment while integrating available observations from tumor cells and other immune populations when relevant, organizing the existing data under current definitions and concepts, and highlighting the challenges of manipulating these pathways to optimize bacterial-based immunotherapies. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_4e4e79e9d20f84d19c09ed289d271496 |
| identifier_str_mv | MÓNACO, A., CHILIBROSTE, S., PLATA, MA., y otros. Salmonella-Induced Cell Death in Cancer Immunotherapy: What Lies Beneath?. Biomedicines [en línea] 2026, 14. DOI: 10.3390/biomedicines14010012 10.3390/biomedicines14010012 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/53273 |
| publishDate | 2026 |
| publishDateSort | 2026 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Salmonella-Induced Cell Death in Cancer Immunotherapy: What Lies Beneath?Mónaco, AmyChilibroste, SofíaPlata, María ClaraChabalgoity, Jose AlejandroMoreno, MaríaSalmonellaCancer immunotherapyCell deathApoptosisPyroptosisAutophagyBacteria-based cancer immunotherapies are regaining attention due to recent advances in understanding the mechanisms underlying their efficacy, making them promising tools for cancer treatment. Among these, Salmonella stands out as one of the most extensively studied microorganisms in this field. Its ability to directly induce tumor cell death while stimulating the immune system offers unique therapeutic advantages, as cell death within an inflamma- tory environment may enhance the release of tumor antigens and promote effective antitu- mor immune responses. Although multiple studies have addressed Salmonella-induced cell death, the nomenclature and classification of death modalities are often inconsistent—either because earlier reports predate the formalization of certain death pathways, or due to over- lapping criteria between different types of cell death. This review aims to comprehensively analyze the available evidence on Salmonella-induced apoptosis, pyroptosis and autophagy, as well as other less characterized death modalities. Given that most mechanistics evidence on Salmonella-induced cell death has been generated in myeloid cells, we primarily focus on the myeloid compartment while integrating available observations from tumor cells and other immune populations when relevant, organizing the existing data under current definitions and concepts, and highlighting the challenges of manipulating these pathways to optimize bacterial-based immunotherapies.Agencia Nacional de Investigación e Innovación (ANII)Mónaco Amy, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Desarrollo BiotecnológicoChilibroste Sofía, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Desarrollo BiotecnológicoPlata María Clara, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Desarrollo BiotecnológicoChabalgoity Jose Alejandro, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Desarrollo BiotecnológicoMoreno María, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Desarrollo Biotecnológico2026-01-20T18:10:02Z2026-01-20T18:10:02Z2026Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfMÓNACO, A., CHILIBROSTE, S., PLATA, MA., y otros. Salmonella-Induced Cell Death in Cancer Immunotherapy: What Lies Beneath?. Biomedicines [en línea] 2026, 14. DOI: 10.3390/biomedicines14010012https://hdl.handle.net/20.500.12008/5327310.3390/biomedicines14010012reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengBiomedicines.14, 2026Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)oai:colibri.udelar.edu.uy:20.500.12008/532732026-04-14T10:37:07Z |
| spellingShingle | Salmonella-Induced Cell Death in Cancer Immunotherapy: What Lies Beneath? Mónaco, Amy Salmonella Cancer immunotherapy Cell death Apoptosis Pyroptosis Autophagy |
| status_str | publishedVersion |
| title | Salmonella-Induced Cell Death in Cancer Immunotherapy: What Lies Beneath? |
| title_full | Salmonella-Induced Cell Death in Cancer Immunotherapy: What Lies Beneath? |
| title_fullStr | Salmonella-Induced Cell Death in Cancer Immunotherapy: What Lies Beneath? |
| title_full_unstemmed | Salmonella-Induced Cell Death in Cancer Immunotherapy: What Lies Beneath? |
| title_short | Salmonella-Induced Cell Death in Cancer Immunotherapy: What Lies Beneath? |
| title_sort | Salmonella-Induced Cell Death in Cancer Immunotherapy: What Lies Beneath? |
| topic | Salmonella Cancer immunotherapy Cell death Apoptosis Pyroptosis Autophagy |
| url | https://hdl.handle.net/20.500.12008/53273 |