PKD2L1 channels segregated to the apical compartment are the exclusive dual-mode pH sensor in cerebrospinal fluid-contacting neurons

Cerebrospinal fluid contacting neurons (CSFcNs) are GABAergic cells that surround the central canal (CC) of the spinal cord. Their soma is located sub-ependymally and they have a dendritic-like process that ends as a bulb (the so-called “apical process”; ApPr) inside the CC. It remains unclear how t...

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Bibliographic Details

Main Author:	Vitar, Magdalena (author)
Other Authors:	Prieto, Daniel (author), Malas, Stavros (author), Russo, Raúl E. (author), Trigo, Federico F. (author)
Format:	article
Language:	English
Published:	2026
Subjects:	neuronas, percepción de pH, PKD2L1, médula espinal Ciencias Médicas y de la Salud Medicina Básica Neurociencias Ciencias Naturales y Exactas Ciencias Biológicas Biología Celular, Microbiología
Online Access:	https://hdl.handle.net/20.500.12381/5453 https://doi.org/10.7554/eLife.109372
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