Substrate recognition properties from an intermediate structural state of the UreA transporter

Through a combination of comparative modeling, site-directed and classical random mutagenesis approaches, we previously identified critical residues for binding, recognition, and translocation of urea, and its inhibition by 2-thiourea and acetamide in the Aspergillus nidulans urea transporter, UreA....

Ausführliche Beschreibung

Bibliographische Detailangaben

1. Verfasser:	Sanguinetti Miralles, Manuel (author)
Weitere Verfasser:	Silva Santos, Lucianna Helene (author), Dourron, Juliette (author), Alamón Lima, Catalina Isadora (author), Idiarte Montiel, Juan (author), Amillis, Sotiris (author), Pantano, Sergio (author), Ramón, Ana (author)
Format:	article
Sprache:	Englisch
Veröffentlicht:	2022
Schlagworte:	Aspergillus nidulans Urea transport AlphaFold2 Binding site Molecular docking
Online-Zugang:	https://hdl.handle.net/20.500.12008/41370
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