The epithelial sodium channel and the processes of wound healing
The epithelial sodium channel (ENaC) mediates passive sodium transport across the apical membranes of sodium absorbing epithelia, like the distal nephron, the intestine, and the lung airways. Additionally, the channel has been involved in the transduction of mechanical stimuli, such as hydrostatic p...
Saved in:
| Hovedforfatter: | |
|---|---|
| Andre forfattere: | |
| Format: | article |
| Sprog: | engelsk |
| Udgivet: |
2016
|
| Fag: | |
| Online adgang: | https://hdl.handle.net/20.500.12008/22103 |
| Tags: |
Ingen Tags, Vær først til at tagge denne postø!
|
| _version_ | 1868890019799760896 |
|---|---|
| author | Chifflet, Silvia |
| author2 | Hernández Garrido, Julio Andrés |
| author2_role | author |
| author_browse | Chifflet, Silvia Hernández Garrido, Julio Andrés |
| author_facet | Chifflet, Silvia Hernández Garrido, Julio Andrés |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Chifflet, Silvia. Universidad de la República (Uruguay). Facultad de Medicina Hernández Garrido, Julio Andrés. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología |
| dc.creator.none.fl_str_mv | Chifflet, Silvia Hernández Garrido, Julio Andrés |
| dc.date.none.fl_str_mv | 2016 2019-10-02T22:14:54Z 2019-10-02T22:14:54Z 20191001 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Chifflet, S., Hernandez, J.The epithelial sodium channel and the processes of wound healing. BioMed Research International, 2016, art. no. 5675047. doi: 10.1155/2016/5675047 2314-6133 https://hdl.handle.net/20.500.12008/22103 10.1155/2016/5675047 |
| dc.language.none.fl_str_mv | en eng |
| dc.publisher.none.fl_str_mv | Hindawi Publishing Corporation |
| dc.relation.none.fl_str_mv | BioMed Research International, 2016, art. no. 5675047 |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución (CC –BY 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Epithelial sodium channel Cell communication |
| dc.title.none.fl_str_mv | The epithelial sodium channel and the processes of wound healing |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | The epithelial sodium channel (ENaC) mediates passive sodium transport across the apical membranes of sodium absorbing epithelia, like the distal nephron, the intestine, and the lung airways. Additionally, the channel has been involved in the transduction of mechanical stimuli, such as hydrostatic pressure, membrane stretch, and shear stress from fluid flow. Thus, in vascular endothelium, it participates in the control of the vascular tone via its activity both as a sodium channel and as a shear stress transducer. Rather recently, ENaC has been shown to participate in the processes of wound healing, a role that may also involve its activities as sodium transporter and as mechanotransducer. Its presence as the sole channel mediating sodium transport in many tissues and the diversity of its functions probably underlie the complexity of its regulation. This brief review describes some aspects of ENaC regulation, comments on evidence about ENaC participation in wound healing, and suggests possible regulatory mechanisms involved in this participation. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_41586d5aa1a210db5abbc2edaa708b83 |
| identifier_str_mv | Chifflet, S., Hernandez, J.The epithelial sodium channel and the processes of wound healing. BioMed Research International, 2016, art. no. 5675047. doi: 10.1155/2016/5675047 2314-6133 10.1155/2016/5675047 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/22103 |
| publishDate | 2016 |
| publishDateSort | 2016 |
| publisher.none.fl_str_mv | Hindawi Publishing Corporation |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC –BY 4.0) |
| spelling | The epithelial sodium channel and the processes of wound healingChifflet, SilviaHernández Garrido, Julio AndrésEpithelial sodium channelCell communicationThe epithelial sodium channel (ENaC) mediates passive sodium transport across the apical membranes of sodium absorbing epithelia, like the distal nephron, the intestine, and the lung airways. Additionally, the channel has been involved in the transduction of mechanical stimuli, such as hydrostatic pressure, membrane stretch, and shear stress from fluid flow. Thus, in vascular endothelium, it participates in the control of the vascular tone via its activity both as a sodium channel and as a shear stress transducer. Rather recently, ENaC has been shown to participate in the processes of wound healing, a role that may also involve its activities as sodium transporter and as mechanotransducer. Its presence as the sole channel mediating sodium transport in many tissues and the diversity of its functions probably underlie the complexity of its regulation. This brief review describes some aspects of ENaC regulation, comments on evidence about ENaC participation in wound healing, and suggests possible regulatory mechanisms involved in this participation.Hindawi Publishing CorporationChifflet, Silvia. Universidad de la República (Uruguay). Facultad de MedicinaHernández Garrido, Julio Andrés. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología2019-10-02T22:14:54Z2019-10-02T22:14:54Z201620191001Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfChifflet, S., Hernandez, J.The epithelial sodium channel and the processes of wound healing. BioMed Research International, 2016, art. no. 5675047. doi: 10.1155/2016/56750472314-6133https://hdl.handle.net/20.500.12008/2210310.1155/2016/5675047reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengBioMed Research International, 2016, art. no. 5675047Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad De La República. (Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC –BY 4.0)oai:colibri.udelar.edu.uy:20.500.12008/221032026-04-14T10:09:21Z |
| spellingShingle | The epithelial sodium channel and the processes of wound healing Chifflet, Silvia Epithelial sodium channel Cell communication |
| status_str | publishedVersion |
| title | The epithelial sodium channel and the processes of wound healing |
| title_full | The epithelial sodium channel and the processes of wound healing |
| title_fullStr | The epithelial sodium channel and the processes of wound healing |
| title_full_unstemmed | The epithelial sodium channel and the processes of wound healing |
| title_short | The epithelial sodium channel and the processes of wound healing |
| title_sort | The epithelial sodium channel and the processes of wound healing |
| topic | Epithelial sodium channel Cell communication |
| url | https://hdl.handle.net/20.500.12008/22103 |