Imaxe de Portada

Signal-sensing triggers the shutdown of HemKR, regulating heme and iron metabolism in the spirochete Leptospira biflexa.

ABSTRACT.- Heme and iron metabolic pathways are highly intertwined, both compounds being essential for key biological processes, yet becoming toxic if overabundant.Their concentrations are exquisitely regulated, including via dedicated two-component systems (TCSs) that sense signals and regulate ada...

Descrición completa

Gardado en:
Autor Principal: IMELIO, J. A. (author)
Outros autores: TRAJTENBERG, F. (author), MONDINO, S. (author), ZARANTONELLI, L. (author), VITRENKO, I. (author), LEMÉE, L. (author), COKELAER, T. (author), PICARDEAU, M. (author), BUSCHIAZZO, A. (author)
Formato: article
Idioma:inglés
Publicado: 2024
Subjects:
Leptospira
Bacterial Proteins
RNA extraction
RNA sequence
UNIDAD MIXTA PASTEUR + INIA
Acceso en liña:https://ainfo.inia.uy/consulta/busca?b=pc&id=64902&biblioteca=vazio&busca=64902&qFacets=64902
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!
_version_ 1868890016646692864
author IMELIO, J. A.
author2 TRAJTENBERG, F.
MONDINO, S.
ZARANTONELLI, L.
VITRENKO, I.
LEMÉE, L.
COKELAER, T.
PICARDEAU, M.
BUSCHIAZZO, A.
author2_role author
author
author
author
author
author
author
author
author_browse BUSCHIAZZO, A.
COKELAER, T.
IMELIO, J. A.
LEMÉE, L.
MONDINO, S.
PICARDEAU, M.
TRAJTENBERG, F.
VITRENKO, I.
ZARANTONELLI, L.
author_facet IMELIO, J. A.
TRAJTENBERG, F.
MONDINO, S.
ZARANTONELLI, L.
VITRENKO, I.
LEMÉE, L.
COKELAER, T.
PICARDEAU, M.
BUSCHIAZZO, A.
author_role author
collection AINFO
dc.creator.none.fl_str_mv IMELIO, J. A.
TRAJTENBERG, F.
MONDINO, S.
ZARANTONELLI, L.
VITRENKO, I.
LEMÉE, L.
COKELAER, T.
PICARDEAU, M.
BUSCHIAZZO, A.
dc.date.none.fl_str_mv 2024
2025-06-23T18:44:45Z
2025-06-23T18:44:45Z
2025-06-23T18:44:45Z
dc.identifier.none.fl_str_mv https://ainfo.inia.uy/consulta/busca?b=pc&id=64902&biblioteca=vazio&busca=64902&qFacets=64902
dc.language.none.fl_str_mv en
eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Acceso abierto
dc.source.none.fl_str_mv reponame:AINFO
instname:Instituto Nacional de Investigación Agropecuaria
instacron:Instituto Nacional de Investigación Agropecuaria
dc.subject.none.fl_str_mv Leptospira
Bacterial Proteins
RNA extraction
RNA sequence
UNIDAD MIXTA PASTEUR + INIA
dc.title.none.fl_str_mv Signal-sensing triggers the shutdown of HemKR, regulating heme and iron metabolism in the spirochete Leptospira biflexa.
dc.type.none.fl_str_mv Article
PublishedVersion
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
description ABSTRACT.- Heme and iron metabolic pathways are highly intertwined, both compounds being essential for key biological processes, yet becoming toxic if overabundant.Their concentrations are exquisitely regulated, including via dedicated two-component systems (TCSs) that sense signals and regulate adaptive responses.HemKR is a TCS present in both saprophytic and pathogenic Leptospira species, involved in the control of heme metabolism.However, the molecular means by which HemKR is switched on/off in a signal-dependent way, are still unknown.Moreover, a comprehensive list of HemKR-regulated genes, potentially overlapped with iron-responsive targets, is also missing. © 2024 Imelio et al.
eu_rights_str_mv openAccess
format article
id anni_3e7d6fdd522cb578dcefeff6a50c3c1d
instacron_str Instituto Nacional de Investigación Agropecuaria
institution Instituto Nacional de Investigación Agropecuaria
instname_str Instituto Nacional de Investigación Agropecuaria
language eng
language_invalid_str_mv en
network_acronym_str anni
network_name_str oai-lr-anni
oai_identifier_str oai:redi.anii.org.uy:20.500.12381/4908
publishDate 2024
publishDateSort 2024
reponame_str AINFO
repository.mail.fl_str_mv
repository.name.fl_str_mv
repository_id_str
rights_invalid_str_mv Acceso abierto
spelling Signal-sensing triggers the shutdown of HemKR, regulating heme and iron metabolism in the spirochete Leptospira biflexa.IMELIO, J. A.TRAJTENBERG, F.MONDINO, S.ZARANTONELLI, L.VITRENKO, I.LEMÉE, L.COKELAER, T.PICARDEAU, M.BUSCHIAZZO, A.LeptospiraBacterial ProteinsRNA extractionRNA sequenceUNIDAD MIXTA PASTEUR + INIAABSTRACT.- Heme and iron metabolic pathways are highly intertwined, both compounds being essential for key biological processes, yet becoming toxic if overabundant.Their concentrations are exquisitely regulated, including via dedicated two-component systems (TCSs) that sense signals and regulate adaptive responses.HemKR is a TCS present in both saprophytic and pathogenic Leptospira species, involved in the control of heme metabolism.However, the molecular means by which HemKR is switched on/off in a signal-dependent way, are still unknown.Moreover, a comprehensive list of HemKR-regulated genes, potentially overlapped with iron-responsive targets, is also missing. © 2024 Imelio et al.2025-06-23T18:44:45Z2025-06-23T18:44:45Z20242025-06-23T18:44:45ZArticlePublishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://ainfo.inia.uy/consulta/busca?b=pc&id=64902&biblioteca=vazio&busca=64902&qFacets=64902reponame:AINFOinstname:Instituto Nacional de Investigación Agropecuariainstacron:Instituto Nacional de Investigación Agropecuariaenenginfo:eu-repo/semantics/openAccessAcceso abiertooai:redi.anii.org.uy:20.500.12381/49082026-02-10T17:36:47Z
spellingShingle Signal-sensing triggers the shutdown of HemKR, regulating heme and iron metabolism in the spirochete Leptospira biflexa.
IMELIO, J. A.
Leptospira
Bacterial Proteins
RNA extraction
RNA sequence
UNIDAD MIXTA PASTEUR + INIA
status_str publishedVersion
title Signal-sensing triggers the shutdown of HemKR, regulating heme and iron metabolism in the spirochete Leptospira biflexa.
title_full Signal-sensing triggers the shutdown of HemKR, regulating heme and iron metabolism in the spirochete Leptospira biflexa.
title_fullStr Signal-sensing triggers the shutdown of HemKR, regulating heme and iron metabolism in the spirochete Leptospira biflexa.
title_full_unstemmed Signal-sensing triggers the shutdown of HemKR, regulating heme and iron metabolism in the spirochete Leptospira biflexa.
title_short Signal-sensing triggers the shutdown of HemKR, regulating heme and iron metabolism in the spirochete Leptospira biflexa.
title_sort Signal-sensing triggers the shutdown of HemKR, regulating heme and iron metabolism in the spirochete Leptospira biflexa.
topic Leptospira
Bacterial Proteins
RNA extraction
RNA sequence
UNIDAD MIXTA PASTEUR + INIA
url https://ainfo.inia.uy/consulta/busca?b=pc&id=64902&biblioteca=vazio&busca=64902&qFacets=64902

Títulos similares