3R's applied to in vivo biological activity of recombinant human erythropoietin assay.

ABSTRACT.- An enhanced protocol for the evaluation of in vivo biological activity of recombinant human erythropoietin (rhEPO) assay in mice is described, following European Pharmacopoeia (Ph. Eur.) version 10.0 guideline and optimized by applying the principles of Replacement, Reduction and Refineme...

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Bibliographic Details

Main Author:	AREVALO, A.P. (author)
Other Authors:	BASIKA, T. (author), ANCHETA, S. (author), PERELMUTER, K. (author), RICCIARDI, A. (author), BOLLATI-FOGOLÍN, M. (author), CRISPO, M. (author)
Format:	article
Language:	English
Published:	2023
Subjects:	3R’s Biological activity Erythropoietin European Pharmacopeia Mice UNIDAD MIXTA PASTEUR + INIA
Online Access:	https://ainfo.inia.uy/consulta/busca?b=pc&id=64596&biblioteca=vazio&busca=64596&qFacets=64596
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