A quantitative systematic review on the analgesic efficacy and adverse effects of ketorolac in third molar surgery.
Objectives: This study aimed to determine the number needed to treat (NNT) of ketorolac in comparison to placebo after third molar surgery. Methods: Studies located in PubMed, Scopus, and Web of Science were evaluated with the Cochrane Risk of Bias assessment tool. Data on the onset of analgesia, th...
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| Other Authors: | , , , , , , , |
| Format: | article |
| Language: | English |
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2025
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| Online Access: | https://hdl.handle.net/20.500.12008/51903 |
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| _version_ | 1868890006437756928 |
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| author | Isiordia-Espinoza, Mario Alberto |
| author2 | Aragon-Martinez, Othoniel Hugo Serafín-Higuera, Nicolás López-Verdín, Sandra Gómez Sánchez, Eduardo Molina-Frechero, Nelly Bologna-Molina, Ronell Guzmán-Flores, Juan Manuel Mora-Falcón, Itzel Joselyn |
| author2_role | author author author author author author author author |
| author_browse | Aragon-Martinez, Othoniel Hugo Bologna-Molina, Ronell Guzmán-Flores, Juan Manuel Gómez Sánchez, Eduardo Isiordia-Espinoza, Mario Alberto López-Verdín, Sandra Molina-Frechero, Nelly Mora-Falcón, Itzel Joselyn Serafín-Higuera, Nicolás |
| author_facet | Isiordia-Espinoza, Mario Alberto Aragon-Martinez, Othoniel Hugo Serafín-Higuera, Nicolás López-Verdín, Sandra Gómez Sánchez, Eduardo Molina-Frechero, Nelly Bologna-Molina, Ronell Guzmán-Flores, Juan Manuel Mora-Falcón, Itzel Joselyn |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Isiordia-Espinoza Mario Alberto, Universidad de Guadalajara (México). Aragon-Martinez Othoniel Hugo, Universidad Autónoma de San Luis Potosí (México). Serafín-Higuera Nicolás, Universidad Autónoma de Baja California (México). López-Verdín Sandra, Universidad de Guadalajara (México). Gómez Sánchez Eduardo, Universidad de Guadalajara (México). Molina-Frechero Nelly, Universidad Autónoma Metropolitana-Unidad Xochimilco (México). Bologna-Molina Ronell, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral. Guzmán-Flores Juan Manuel, Universidad de Guadalajara (México). Mora-Falcón Itzel Joselyn, Universidad de Guadalajara (México). |
| dc.creator.none.fl_str_mv | Isiordia-Espinoza, Mario Alberto Aragon-Martinez, Othoniel Hugo Serafín-Higuera, Nicolás López-Verdín, Sandra Gómez Sánchez, Eduardo Molina-Frechero, Nelly Bologna-Molina, Ronell Guzmán-Flores, Juan Manuel Mora-Falcón, Itzel Joselyn |
| dc.date.none.fl_str_mv | 2025-10-03T17:55:45Z 2025-10-03T17:55:45Z 2025 |
| dc.format.none.fl_str_mv | 12 h. application/pdf |
| dc.identifier.none.fl_str_mv | Isiordia-Espinoza, M, Aragon-Martinez, O, Serafín-Higuera, N [y otros autores]. "A quantitative systematic review on the analgesic efficacy and adverse effects of ketorolac in third molar surgery". Clinics and Practice. [en línea] 2025. 15(4): 81. 12 h. https://hdl.handle.net/20.500.12008/51903 10.3390/clinpract15040081 2039-7283 |
| dc.language.none.fl_str_mv | en eng |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.relation.none.fl_str_mv | Clinics and Practice, 2025, 15(4): 81. |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Ketorolac Postoperative dental pain KETOROLACO PLACEBOS ODONTALGIA METAANALISIS |
| dc.title.none.fl_str_mv | A quantitative systematic review on the analgesic efficacy and adverse effects of ketorolac in third molar surgery. |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Objectives: This study aimed to determine the number needed to treat (NNT) of ketorolac in comparison to placebo after third molar surgery. Methods: Studies located in PubMed, Scopus, and Web of Science were evaluated with the Cochrane Risk of Bias assessment tool. Data on the onset of analgesia, the number of patients requiring rescue medication, the global or general evaluation of the study medication, and adverse effects were extracted. Data analysis was performed using Review Manager 5.3 software for Windows. Results: The qualitative assessment of the included studies showed that ketorolac was more effective than a placebo and the quantitative evaluation on the onset of analgesia (NNT = 1.6 (95%CIs = 1.4, 1.9), n = 301), the number of patients who took rescue analgesics (NNT = 3.6 (95%CIs = 2.8 to 4.9), n = 563), and the global evaluation of the treatments (NNT = 1.7 (95%CIs = 1.5 to 1.9), n = 475) showed estimates of analgesic efficacy with a statistical difference in favor of ketorolac when compared with a placebo. No statistical difference was observed in adverse effects between ketorolac and placebo (n = 739). Conclusions: There is scientific evidence of moderate quality that allows estimators of the analgesic efficacy of ketorolac to be calculated, which will significantly help the clinician who performs pharmacological treatment after third molar surgery. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_36d398aeeb80a8090c8190896e0f29b4 |
| identifier_str_mv | Isiordia-Espinoza, M, Aragon-Martinez, O, Serafín-Higuera, N [y otros autores]. "A quantitative systematic review on the analgesic efficacy and adverse effects of ketorolac in third molar surgery". Clinics and Practice. [en línea] 2025. 15(4): 81. 12 h. 10.3390/clinpract15040081 2039-7283 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/51903 |
| publishDate | 2025 |
| publishDateSort | 2025 |
| publisher.none.fl_str_mv | MDPI |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | A quantitative systematic review on the analgesic efficacy and adverse effects of ketorolac in third molar surgery.Isiordia-Espinoza, Mario AlbertoAragon-Martinez, Othoniel HugoSerafín-Higuera, NicolásLópez-Verdín, SandraGómez Sánchez, EduardoMolina-Frechero, NellyBologna-Molina, RonellGuzmán-Flores, Juan ManuelMora-Falcón, Itzel JoselynKetorolacPostoperative dental painKETOROLACOPLACEBOSODONTALGIAMETAANALISISObjectives: This study aimed to determine the number needed to treat (NNT) of ketorolac in comparison to placebo after third molar surgery. Methods: Studies located in PubMed, Scopus, and Web of Science were evaluated with the Cochrane Risk of Bias assessment tool. Data on the onset of analgesia, the number of patients requiring rescue medication, the global or general evaluation of the study medication, and adverse effects were extracted. Data analysis was performed using Review Manager 5.3 software for Windows. Results: The qualitative assessment of the included studies showed that ketorolac was more effective than a placebo and the quantitative evaluation on the onset of analgesia (NNT = 1.6 (95%CIs = 1.4, 1.9), n = 301), the number of patients who took rescue analgesics (NNT = 3.6 (95%CIs = 2.8 to 4.9), n = 563), and the global evaluation of the treatments (NNT = 1.7 (95%CIs = 1.5 to 1.9), n = 475) showed estimates of analgesic efficacy with a statistical difference in favor of ketorolac when compared with a placebo. No statistical difference was observed in adverse effects between ketorolac and placebo (n = 739). Conclusions: There is scientific evidence of moderate quality that allows estimators of the analgesic efficacy of ketorolac to be calculated, which will significantly help the clinician who performs pharmacological treatment after third molar surgery.MDPIIsiordia-Espinoza Mario Alberto, Universidad de Guadalajara (México).Aragon-Martinez Othoniel Hugo, Universidad Autónoma de San Luis Potosí (México).Serafín-Higuera Nicolás, Universidad Autónoma de Baja California (México).López-Verdín Sandra, Universidad de Guadalajara (México).Gómez Sánchez Eduardo, Universidad de Guadalajara (México).Molina-Frechero Nelly, Universidad Autónoma Metropolitana-Unidad Xochimilco (México).Bologna-Molina Ronell, Universidad de la República (Uruguay). Facultad de Odontología. Departamento de Diagnóstico en Patología y Medicina Oral.Guzmán-Flores Juan Manuel, Universidad de Guadalajara (México).Mora-Falcón Itzel Joselyn, Universidad de Guadalajara (México).2025-10-03T17:55:45Z2025-10-03T17:55:45Z2025Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion12 h.application/pdfIsiordia-Espinoza, M, Aragon-Martinez, O, Serafín-Higuera, N [y otros autores]. "A quantitative systematic review on the analgesic efficacy and adverse effects of ketorolac in third molar surgery". Clinics and Practice. [en línea] 2025. 15(4): 81. 12 h.https://hdl.handle.net/20.500.12008/5190310.3390/clinpract150400812039-7283reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengClinics and Practice, 2025, 15(4): 81.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)oai:colibri.udelar.edu.uy:20.500.12008/519032026-04-14T10:37:16Z |
| spellingShingle | A quantitative systematic review on the analgesic efficacy and adverse effects of ketorolac in third molar surgery. Isiordia-Espinoza, Mario Alberto Ketorolac Postoperative dental pain KETOROLACO PLACEBOS ODONTALGIA METAANALISIS |
| status_str | publishedVersion |
| title | A quantitative systematic review on the analgesic efficacy and adverse effects of ketorolac in third molar surgery. |
| title_full | A quantitative systematic review on the analgesic efficacy and adverse effects of ketorolac in third molar surgery. |
| title_fullStr | A quantitative systematic review on the analgesic efficacy and adverse effects of ketorolac in third molar surgery. |
| title_full_unstemmed | A quantitative systematic review on the analgesic efficacy and adverse effects of ketorolac in third molar surgery. |
| title_short | A quantitative systematic review on the analgesic efficacy and adverse effects of ketorolac in third molar surgery. |
| title_sort | A quantitative systematic review on the analgesic efficacy and adverse effects of ketorolac in third molar surgery. |
| topic | Ketorolac Postoperative dental pain KETOROLACO PLACEBOS ODONTALGIA METAANALISIS |
| url | https://hdl.handle.net/20.500.12008/51903 |