Epidemiology of Meningococcal Disease in Four South American Countries and Rationale of Vaccination in Adolescents from the Region: Position Paper of the Latin American Society of Pediatric Infectious Diseases (SLIPE)
Surveillance of meningococcal disease (MD) is crucial after the implementation of vaccination strategies to monitor their impact on disease burden. Adolescent vaccination could provide direct and indirect protection. Argentina, Brazil, and Chile have introduced meningococcal conjugate vaccines (MCV)...
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| Format: | article |
| Sprog: | engelsk |
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2023
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| Online adgang: | https://hdl.handle.net/20.500.12008/54287 |
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| _version_ | 1868890005150105600 |
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| author | Villena, Rodolfo |
| author2 | Safadi, Marco Aurelio Gentile, Ángela Pujadas, Mónica De la Maza, Verónica George, Sergio Torres, Juan Pablo |
| author2_role | author author author author author author |
| author_browse | De la Maza, Verónica Gentile, Ángela George, Sergio Pujadas, Mónica Safadi, Marco Aurelio Torres, Juan Pablo Villena, Rodolfo |
| author_facet | Villena, Rodolfo Safadi, Marco Aurelio Gentile, Ángela Pujadas, Mónica De la Maza, Verónica George, Sergio Torres, Juan Pablo |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Villena Rodolfo, Hospital de Niños Exequiel González Cortés (Chile) Safadi Marco Aurelio, Faculdade de Ciências Médicas da Santa Casa de São Paulo (Brasil) Gentile Ángela, Universidad de Buenos Aires (Argentina). Facultad de Medicina, Departamento de Epidemiología Pujadas Mónica, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Epidemiología y Enfermedades Infecciosas Pediátricas De la Maza Verónica, Universidad de Chile (Chile). Facultad de Medicina, Departamento de Pediatría George Sergio, Universidad de Chile (Chile). Facultad de Medicina, Departamento de Pediatría Torres Juan Pablo, Universidad de Chile (Chile). Facultad de Medicina, Departamento de Pediatría |
| dc.coverage.none.fl_str_mv | SUDAMÉRICA AMÉRICA DEL SUR ARGENTINA BRASIL CHILE URUGUAY |
| dc.creator.none.fl_str_mv | Villena, Rodolfo Safadi, Marco Aurelio Gentile, Ángela Pujadas, Mónica De la Maza, Verónica George, Sergio Torres, Juan Pablo |
| dc.date.none.fl_str_mv | 2023 2026-04-10T15:29:47Z 2026-04-10T15:29:47Z |
| dc.format.none.fl_str_mv | 14 p. application/pdf |
| dc.identifier.none.fl_str_mv | Villena R, Safadi M, Gentile Á y otros. Epidemiology of Meningococcal Disease in Four South American Countries and Rationale of Vaccination in Adolescents from the Region: Position Paper of the Latin American Society of Pediatric Infectious Diseases (SLIPE). Vaccines [en línea]. 2023;12(11). 14 p. https://hdl.handle.net/20.500.12008/54287 10.3390/vaccines11121841 2076-393X |
| dc.language.none.fl_str_mv | en eng |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.relation.none.fl_str_mv | Vaccines. 2023;12(11) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Neisseria meningitidis Adolescents Epidemiology Meningococcal disease Vaccines INFECCIONES MENINGOCÓCICAS ADOLESCENTES EPIDEMIOLOGÍA VACUNAS |
| dc.title.none.fl_str_mv | Epidemiology of Meningococcal Disease in Four South American Countries and Rationale of Vaccination in Adolescents from the Region: Position Paper of the Latin American Society of Pediatric Infectious Diseases (SLIPE) |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Surveillance of meningococcal disease (MD) is crucial after the implementation of vaccination strategies to monitor their impact on disease burden. Adolescent vaccination could provide direct and indirect protection. Argentina, Brazil, and Chile have introduced meningococcal conjugate vaccines (MCV) into their National Immunization Programs (NIP), while Uruguay has not. Here, we analyze the epidemiology of MD and vaccination experience from these four South American countries to identify needs and plans to improve the current vaccination programs. Methodology: Descriptive study of MD incidence rates, serogroup distribution, case fatality rates (CFR), and MCV uptakes during the period 2010-2021 in Argentina, Brazil, Chile, and Uruguay. Data were extracted from national surveillance programs, reference laboratories, NIPs, and Pubmed. Results: MD overall incidence from 2010 to 2021 have a decreasing trend in Argentina (0.37 [IQR = 0.20-0.61]), Brazil (0.59 [IQR = 0.54-1.22]), and Chile (0.45 [IQR = 0.40-0.77]), while a significant increase in Uruguay (0.47 [IQR = 0.33-0.69]) was found from 2016 to 2019. During the COVID-19 pandemic, all countries sharply reduced their MD incidence. The highest incidence rates were observed among infants, followed by children 1-4 years of age. No second peak was evident in adolescents. A reduction in serogroup C, W, and Y cases has occurred in Argentina, Brazil, and Chile after introduction of MCV, serogroup B becoming predominant in all four countries. Median CFR was 9.0%, 21%, 19.9%, and 17.9% in Argentina, Brazil, Chile, and Uruguay, respectively. Median uptake of MCV for Argentina and Brazil were 66.6% and 91.0% for priming in infants; 54.7% and 84.5% for booster in toddlers; and 47.5% and 53% for adolescents; while for Chile, 95.6% for toddlers. Conclusions: Experience after the implementation of MCV programs in South America was successful, reducing the burden of MD due to the vaccine serogroups. High vaccine uptake and the inclusion of adolescents will be crucial in the post-pandemic period to maintain the protection of the population. The increase in the proportion of serogroup B cases emphasizes the importance of continuous surveillance to guide future vaccination strategies. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_35d2cd15380f9663ff5eec01e3b4c660 |
| identifier_str_mv | Villena R, Safadi M, Gentile Á y otros. Epidemiology of Meningococcal Disease in Four South American Countries and Rationale of Vaccination in Adolescents from the Region: Position Paper of the Latin American Society of Pediatric Infectious Diseases (SLIPE). Vaccines [en línea]. 2023;12(11). 14 p. 10.3390/vaccines11121841 2076-393X |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/54287 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| publisher.none.fl_str_mv | MDPI |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Epidemiology of Meningococcal Disease in Four South American Countries and Rationale of Vaccination in Adolescents from the Region: Position Paper of the Latin American Society of Pediatric Infectious Diseases (SLIPE)Villena, RodolfoSafadi, Marco AurelioGentile, ÁngelaPujadas, MónicaDe la Maza, VerónicaGeorge, SergioTorres, Juan PabloNeisseria meningitidisAdolescentsEpidemiologyMeningococcal diseaseVaccinesINFECCIONES MENINGOCÓCICASADOLESCENTESEPIDEMIOLOGÍAVACUNASSurveillance of meningococcal disease (MD) is crucial after the implementation of vaccination strategies to monitor their impact on disease burden. Adolescent vaccination could provide direct and indirect protection. Argentina, Brazil, and Chile have introduced meningococcal conjugate vaccines (MCV) into their National Immunization Programs (NIP), while Uruguay has not. Here, we analyze the epidemiology of MD and vaccination experience from these four South American countries to identify needs and plans to improve the current vaccination programs. Methodology: Descriptive study of MD incidence rates, serogroup distribution, case fatality rates (CFR), and MCV uptakes during the period 2010-2021 in Argentina, Brazil, Chile, and Uruguay. Data were extracted from national surveillance programs, reference laboratories, NIPs, and Pubmed. Results: MD overall incidence from 2010 to 2021 have a decreasing trend in Argentina (0.37 [IQR = 0.20-0.61]), Brazil (0.59 [IQR = 0.54-1.22]), and Chile (0.45 [IQR = 0.40-0.77]), while a significant increase in Uruguay (0.47 [IQR = 0.33-0.69]) was found from 2016 to 2019. During the COVID-19 pandemic, all countries sharply reduced their MD incidence. The highest incidence rates were observed among infants, followed by children 1-4 years of age. No second peak was evident in adolescents. A reduction in serogroup C, W, and Y cases has occurred in Argentina, Brazil, and Chile after introduction of MCV, serogroup B becoming predominant in all four countries. Median CFR was 9.0%, 21%, 19.9%, and 17.9% in Argentina, Brazil, Chile, and Uruguay, respectively. Median uptake of MCV for Argentina and Brazil were 66.6% and 91.0% for priming in infants; 54.7% and 84.5% for booster in toddlers; and 47.5% and 53% for adolescents; while for Chile, 95.6% for toddlers. Conclusions: Experience after the implementation of MCV programs in South America was successful, reducing the burden of MD due to the vaccine serogroups. High vaccine uptake and the inclusion of adolescents will be crucial in the post-pandemic period to maintain the protection of the population. The increase in the proportion of serogroup B cases emphasizes the importance of continuous surveillance to guide future vaccination strategies.MDPIVillena Rodolfo, Hospital de Niños Exequiel González Cortés (Chile)Safadi Marco Aurelio, Faculdade de Ciências Médicas da Santa Casa de São Paulo (Brasil)Gentile Ángela, Universidad de Buenos Aires (Argentina). Facultad de Medicina, Departamento de EpidemiologíaPujadas Mónica, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Epidemiología y Enfermedades Infecciosas PediátricasDe la Maza Verónica, Universidad de Chile (Chile). Facultad de Medicina, Departamento de PediatríaGeorge Sergio, Universidad de Chile (Chile). Facultad de Medicina, Departamento de PediatríaTorres Juan Pablo, Universidad de Chile (Chile). Facultad de Medicina, Departamento de Pediatría2026-04-10T15:29:47Z2026-04-10T15:29:47Z2023Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion14 p.application/pdfVillena R, Safadi M, Gentile Á y otros. Epidemiology of Meningococcal Disease in Four South American Countries and Rationale of Vaccination in Adolescents from the Region: Position Paper of the Latin American Society of Pediatric Infectious Diseases (SLIPE). Vaccines [en línea]. 2023;12(11). 14 p.https://hdl.handle.net/20.500.12008/5428710.3390/vaccines111218412076-393Xreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengVaccines. 2023;12(11)SUDAMÉRICAAMÉRICA DEL SURARGENTINABRASILCHILEURUGUAYLas obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)oai:colibri.udelar.edu.uy:20.500.12008/542872026-04-14T10:28:29Z |
| spellingShingle | Epidemiology of Meningococcal Disease in Four South American Countries and Rationale of Vaccination in Adolescents from the Region: Position Paper of the Latin American Society of Pediatric Infectious Diseases (SLIPE) Villena, Rodolfo Neisseria meningitidis Adolescents Epidemiology Meningococcal disease Vaccines INFECCIONES MENINGOCÓCICAS ADOLESCENTES EPIDEMIOLOGÍA VACUNAS |
| status_str | publishedVersion |
| title | Epidemiology of Meningococcal Disease in Four South American Countries and Rationale of Vaccination in Adolescents from the Region: Position Paper of the Latin American Society of Pediatric Infectious Diseases (SLIPE) |
| title_full | Epidemiology of Meningococcal Disease in Four South American Countries and Rationale of Vaccination in Adolescents from the Region: Position Paper of the Latin American Society of Pediatric Infectious Diseases (SLIPE) |
| title_fullStr | Epidemiology of Meningococcal Disease in Four South American Countries and Rationale of Vaccination in Adolescents from the Region: Position Paper of the Latin American Society of Pediatric Infectious Diseases (SLIPE) |
| title_full_unstemmed | Epidemiology of Meningococcal Disease in Four South American Countries and Rationale of Vaccination in Adolescents from the Region: Position Paper of the Latin American Society of Pediatric Infectious Diseases (SLIPE) |
| title_short | Epidemiology of Meningococcal Disease in Four South American Countries and Rationale of Vaccination in Adolescents from the Region: Position Paper of the Latin American Society of Pediatric Infectious Diseases (SLIPE) |
| title_sort | Epidemiology of Meningococcal Disease in Four South American Countries and Rationale of Vaccination in Adolescents from the Region: Position Paper of the Latin American Society of Pediatric Infectious Diseases (SLIPE) |
| topic | Neisseria meningitidis Adolescents Epidemiology Meningococcal disease Vaccines INFECCIONES MENINGOCÓCICAS ADOLESCENTES EPIDEMIOLOGÍA VACUNAS |
| url | https://hdl.handle.net/20.500.12008/54287 |