Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay
Introduction and objectives: there is insufficient data regarding bacterial infections in patients with cirrhosis to support recommendations for empiric antibiotic treatments, particularly in Latin America. This study aimed to evaluate bacterial infection's clinical impact and microbiological charac...
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| Médium: | article |
| Jazyk: | angličtina |
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2023
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| On-line přístup: | https://hdl.handle.net/20.500.12008/54288 |
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| _version_ | 1868889996897812480 |
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| author | Vásquez, Carolina |
| author2 | Gutierrez-Acevedo, María Nelly Barbero, Sabrina Notari, Lorena del Carmen Agozino, Marina Fernández, José Luis Anders, María Margarita Grigera, Nadia Lorena Antinucci, Florencia Orozco-Ganem, Orlando Nicolás Federico Murga, María Dolores Pérez, María Daniela Palazzo, Ana Gracia Martinez Rejtman, Liria Duarte, Ivonne Giselle Vorobioff, Julio Daniel Trevizan, Victoria Bulaty, Sofía Bessone, Fernando Valverde, Marcelo Elizondo, Martín Borzi, Silvia Mabel |
| author2_role | author author author author author author author author author author author author author author author author author author author author author |
| author_browse | Agozino, Marina Anders, María Margarita Antinucci, Florencia Barbero, Sabrina Bessone, Fernando Borzi, Silvia Mabel Bulaty, Sofía Duarte, Ivonne Giselle Elizondo, Martín Fernández, José Luis Grigera, Nadia Lorena Gutierrez-Acevedo, María Nelly Martinez Rejtman, Liria Murga, María Dolores Notari, Lorena del Carmen Orozco-Ganem, Orlando Nicolás Federico Palazzo, Ana Gracia Pérez, María Daniela Trevizan, Victoria Valverde, Marcelo Vorobioff, Julio Daniel Vásquez, Carolina |
| author_facet | Vásquez, Carolina Gutierrez-Acevedo, María Nelly Barbero, Sabrina Notari, Lorena del Carmen Agozino, Marina Fernández, José Luis Anders, María Margarita Grigera, Nadia Lorena Antinucci, Florencia Orozco-Ganem, Orlando Nicolás Federico Murga, María Dolores Pérez, María Daniela Palazzo, Ana Gracia Martinez Rejtman, Liria Duarte, Ivonne Giselle Vorobioff, Julio Daniel Trevizan, Victoria Bulaty, Sofía Bessone, Fernando Valverde, Marcelo Elizondo, Martín Borzi, Silvia Mabel |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Vásquez Carolina, Hospital Italiano de Buenos Aires (Argentina) Gutierrez-Acevedo María Nelly, Hospital 4 de Junio (Argentina) Barbero Sabrina, Hospital Churruca Visca (Argentina) Notari Lorena del Carmen, Hospital Churruca Visca (Argentina) Agozino Marina, Sanatorio Güemes (Argentina) Fernández José Luis, Sanatorio Güemes (Argentina) Anders María Margarita, Hospital Alemán (Argentina) Grigera Nadia Lorena, Hospital Alemán (Argentina) Antinucci Florencia, Hospital Alemán (Argentina) Orozco-Ganem Orlando Nicolás Federico, Hospital Alemán (Argentina) Murga María Dolores, Hospital A.C. Padilla (Argentina) Pérez María Daniela, Hospital A.C. Padilla (Argentina) Palazzo Ana Gracia, Hospital A.C. Padilla (Argentina) Martinez Rejtman Liria, Hospital T J Schestakow (Argentina) Duarte Ivonne Giselle, Hospital 4 de Junio (Argentina) Vorobioff Julio Daniel, Hospital Provincial del Centenario (Argentina) Trevizan Victoria, Hospital Provincial del Centenario (Argentina) Bulaty Sofía, Hospital Provincial del Centenario (Argentina) Bessone Fernando, Hospital Provincial del Centenario (Argentina) Valverde Marcelo, Unidad Bi-Institucional de Trasplante Hepático, Hospital de Clínicas - Hospital Militar (Uruguay) Elizondo Martín, Unidad Bi-Institucional de Trasplante Hepático, Hospital de Clínicas - Hospital Militar (Uruguay) Borzi Silvia Mabel, Hospital Rossi (Argentina) |
| dc.coverage.none.fl_str_mv | ARGENTINA URUGUAY |
| dc.creator.none.fl_str_mv | Vásquez, Carolina Gutierrez-Acevedo, María Nelly Barbero, Sabrina Notari, Lorena del Carmen Agozino, Marina Fernández, José Luis Anders, María Margarita Grigera, Nadia Lorena Antinucci, Florencia Orozco-Ganem, Orlando Nicolás Federico Murga, María Dolores Pérez, María Daniela Palazzo, Ana Gracia Martinez Rejtman, Liria Duarte, Ivonne Giselle Vorobioff, Julio Daniel Trevizan, Victoria Bulaty, Sofía Bessone, Fernando Valverde, Marcelo Elizondo, Martín Borzi, Silvia Mabel |
| dc.date.none.fl_str_mv | 2023 2026-04-10T15:31:34Z 2026-04-10T15:31:34Z |
| dc.format.none.fl_str_mv | 8 p. application/pdf |
| dc.identifier.none.fl_str_mv | Vásquez C, Gutiérrez-Acevedo M, Barbero S y otros. Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay. Annals of Hepatology [en línea]. 2023;28(4). 8 p. https://hdl.handle.net/20.500.12008/54288 10.1016/j.aohep.2023.101097 1665-2681 |
| dc.language.none.fl_str_mv | en eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.relation.none.fl_str_mv | Annals of Hepatology. 2023;28(4) |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Antibiotics Antimicrobial agents Multidrug resistance ANTIBACTERIANOS EPIDEMIOLOGÍA USOS TERAPÉUTICOS BACTERIAS INFECCIONES BACTERIANAS DIGNÓSTICO ADMINISTRACIÓN DEL TRATAMIENTO FARMACOLÓGICO INFECCIONES COMUNITARIAS ADQUIRIDAS INFECCIÓN HOSPITALARIA HUMANOS CIRROSIS HEPÁTICA ESTUDIOS PROSPECTIVOS INFECCIONES URINARIAS |
| dc.title.none.fl_str_mv | Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Introduction and objectives: there is insufficient data regarding bacterial infections in patients with cirrhosis to support recommendations for empiric antibiotic treatments, particularly in Latin America. This study aimed to evaluate bacterial infection's clinical impact and microbiological characteristics, intending to serve as a platform to revise current practices. Materials and methods: multicenter prospective cohort study of patients with cirrhosis and bacterial infections from Argentina and Uruguay. Patient and infection-related information were collected, focusing on microbiology, antibiotic susceptibility patterns, and outcomes. Results: 472 patients were included. Spontaneous bacterial infections and urinary tract infections (UTIs) were registered in 187 (39.6%) and 116 (24.6%) patients, respectively, representing the most common infections. Of the 256 culture-positive infections, 103 (40.2%) were caused by multidrug-resistant organisms (reaching 50% for UTI), and 181 (70.7%) received adequate initial antibiotic treatment. The coverage of cefepime and ceftriaxone was over 70% for the empirical treatment of community-acquired spontaneous infections, but ceftazidime´s coverage was only 40%. For all UTI cases and for healthcare-associated or nosocomial spontaneous bacterial infections, the lower-spectrum antibiotics that covered at least 70% of the isolations were imipenem and meropenem. During hospitalization, a second bacterial infection was diagnosed in 9.8% of patients, 23.9% required at least one organ support, and 19.5% died. Conclusions: short-term mortality of bacterial infections in patients with cirrhosis is very high, and a high percentage were caused by multidrug-resistant organisms, particularly in UTIs. The information provided might serve to adapt recommendations, particularly related to empirical antibiotic treatment in Argentina and Uruguay. The study was registered in Clinical Trials (NCT03919032). |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_2daeec75e145a5ee48fe5405e0635c47 |
| identifier_str_mv | Vásquez C, Gutiérrez-Acevedo M, Barbero S y otros. Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay. Annals of Hepatology [en línea]. 2023;28(4). 8 p. 10.1016/j.aohep.2023.101097 1665-2681 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/54288 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| publisher.none.fl_str_mv | Elsevier |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| spelling | Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and UruguayVásquez, CarolinaGutierrez-Acevedo, María NellyBarbero, SabrinaNotari, Lorena del CarmenAgozino, MarinaFernández, José LuisAnders, María MargaritaGrigera, Nadia LorenaAntinucci, FlorenciaOrozco-Ganem, Orlando Nicolás FedericoMurga, María DoloresPérez, María DanielaPalazzo, Ana GraciaMartinez Rejtman, LiriaDuarte, Ivonne GiselleVorobioff, Julio DanielTrevizan, VictoriaBulaty, SofíaBessone, FernandoValverde, MarceloElizondo, MartínBorzi, Silvia MabelAntibioticsAntimicrobial agentsMultidrug resistanceANTIBACTERIANOSEPIDEMIOLOGÍAUSOS TERAPÉUTICOSBACTERIASINFECCIONES BACTERIANASDIGNÓSTICOADMINISTRACIÓN DEL TRATAMIENTO FARMACOLÓGICOINFECCIONES COMUNITARIAS ADQUIRIDASINFECCIÓN HOSPITALARIAHUMANOSCIRROSIS HEPÁTICAESTUDIOS PROSPECTIVOSINFECCIONES URINARIASIntroduction and objectives: there is insufficient data regarding bacterial infections in patients with cirrhosis to support recommendations for empiric antibiotic treatments, particularly in Latin America. This study aimed to evaluate bacterial infection's clinical impact and microbiological characteristics, intending to serve as a platform to revise current practices. Materials and methods: multicenter prospective cohort study of patients with cirrhosis and bacterial infections from Argentina and Uruguay. Patient and infection-related information were collected, focusing on microbiology, antibiotic susceptibility patterns, and outcomes. Results: 472 patients were included. Spontaneous bacterial infections and urinary tract infections (UTIs) were registered in 187 (39.6%) and 116 (24.6%) patients, respectively, representing the most common infections. Of the 256 culture-positive infections, 103 (40.2%) were caused by multidrug-resistant organisms (reaching 50% for UTI), and 181 (70.7%) received adequate initial antibiotic treatment. The coverage of cefepime and ceftriaxone was over 70% for the empirical treatment of community-acquired spontaneous infections, but ceftazidime´s coverage was only 40%. For all UTI cases and for healthcare-associated or nosocomial spontaneous bacterial infections, the lower-spectrum antibiotics that covered at least 70% of the isolations were imipenem and meropenem. During hospitalization, a second bacterial infection was diagnosed in 9.8% of patients, 23.9% required at least one organ support, and 19.5% died. Conclusions: short-term mortality of bacterial infections in patients with cirrhosis is very high, and a high percentage were caused by multidrug-resistant organisms, particularly in UTIs. The information provided might serve to adapt recommendations, particularly related to empirical antibiotic treatment in Argentina and Uruguay. The study was registered in Clinical Trials (NCT03919032).ElsevierVásquez Carolina, Hospital Italiano de Buenos Aires (Argentina)Gutierrez-Acevedo María Nelly, Hospital 4 de Junio (Argentina)Barbero Sabrina, Hospital Churruca Visca (Argentina)Notari Lorena del Carmen, Hospital Churruca Visca (Argentina)Agozino Marina, Sanatorio Güemes (Argentina)Fernández José Luis, Sanatorio Güemes (Argentina)Anders María Margarita, Hospital Alemán (Argentina)Grigera Nadia Lorena, Hospital Alemán (Argentina)Antinucci Florencia, Hospital Alemán (Argentina)Orozco-Ganem Orlando Nicolás Federico, Hospital Alemán (Argentina)Murga María Dolores, Hospital A.C. Padilla (Argentina)Pérez María Daniela, Hospital A.C. Padilla (Argentina)Palazzo Ana Gracia, Hospital A.C. Padilla (Argentina)Martinez Rejtman Liria, Hospital T J Schestakow (Argentina)Duarte Ivonne Giselle, Hospital 4 de Junio (Argentina)Vorobioff Julio Daniel, Hospital Provincial del Centenario (Argentina)Trevizan Victoria, Hospital Provincial del Centenario (Argentina)Bulaty Sofía, Hospital Provincial del Centenario (Argentina)Bessone Fernando, Hospital Provincial del Centenario (Argentina)Valverde Marcelo, Unidad Bi-Institucional de Trasplante Hepático, Hospital de Clínicas - Hospital Militar (Uruguay)Elizondo Martín, Unidad Bi-Institucional de Trasplante Hepático, Hospital de Clínicas - Hospital Militar (Uruguay)Borzi Silvia Mabel, Hospital Rossi (Argentina)2026-04-10T15:31:34Z2026-04-10T15:31:34Z2023Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion8 p.application/pdfVásquez C, Gutiérrez-Acevedo M, Barbero S y otros. Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay. Annals of Hepatology [en línea]. 2023;28(4). 8 p.https://hdl.handle.net/20.500.12008/5428810.1016/j.aohep.2023.1010971665-2681reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengAnnals of Hepatology. 2023;28(4)ARGENTINAURUGUAYLas obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)oai:colibri.udelar.edu.uy:20.500.12008/542882026-04-14T10:28:29Z |
| spellingShingle | Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay Vásquez, Carolina Antibiotics Antimicrobial agents Multidrug resistance ANTIBACTERIANOS EPIDEMIOLOGÍA USOS TERAPÉUTICOS BACTERIAS INFECCIONES BACTERIANAS DIGNÓSTICO ADMINISTRACIÓN DEL TRATAMIENTO FARMACOLÓGICO INFECCIONES COMUNITARIAS ADQUIRIDAS INFECCIÓN HOSPITALARIA HUMANOS CIRROSIS HEPÁTICA ESTUDIOS PROSPECTIVOS INFECCIONES URINARIAS |
| status_str | publishedVersion |
| title | Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay |
| title_full | Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay |
| title_fullStr | Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay |
| title_full_unstemmed | Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay |
| title_short | Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay |
| title_sort | Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay |
| topic | Antibiotics Antimicrobial agents Multidrug resistance ANTIBACTERIANOS EPIDEMIOLOGÍA USOS TERAPÉUTICOS BACTERIAS INFECCIONES BACTERIANAS DIGNÓSTICO ADMINISTRACIÓN DEL TRATAMIENTO FARMACOLÓGICO INFECCIONES COMUNITARIAS ADQUIRIDAS INFECCIÓN HOSPITALARIA HUMANOS CIRROSIS HEPÁTICA ESTUDIOS PROSPECTIVOS INFECCIONES URINARIAS |
| url | https://hdl.handle.net/20.500.12008/54288 |