Insulin-like growth factor-I (IGF-I) and thioredoxin are differentially expressed along the reproductive tract of the ewe during the oestrous cycle and after ovariectomy
Insulin-like growth factor-I (IGF-I) and thioredoxin are regulated by gonadal steroids in the female reproductive tract of many species. Oestradiol regulates IGF-I and thioredoxin mRNA levels in the reproductive tract of prepubertal lambs. The physiological status (different endocrine environment) m...
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| Format: | article |
| Language: | English |
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2006
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| Online Access: | https://hdl.handle.net/20.500.12008/50679 |
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| _version_ | 1868889979721089024 |
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| author | Van Lier, Elize |
| author2 | Meikle, Ana Eriksson, Håkan Sahlin, L |
| author2_role | author author author |
| author_browse | Eriksson, Håkan Meikle, Ana Sahlin, L Van Lier, Elize |
| author_facet | Van Lier, Elize Meikle, Ana Eriksson, Håkan Sahlin, L |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Van Lier Elize, Universidad de la República (Uruguay). Faculty of Agriculture. Animal and Forage Sciences Department Meikle Ana, Universidad de la República (Uruguay). Veterinary Faculty. Department of Molecular and Cellular Biology Eriksson Håkan, Karolinska Institutet (Stockholm, Sweden). Department of Woman and Child Health. Division for Reproductive Endocrinology Sahlin L, Karolinska Institutet (Stockholm, Sweden). Department of Woman and Child Health. Division for Reproductive Endocrinology |
| dc.creator.none.fl_str_mv | Van Lier, Elize Meikle, Ana Eriksson, Håkan Sahlin, L |
| dc.date.none.fl_str_mv | 2006 2025-07-21T12:46:48Z 2025-07-21T12:46:48Z |
| dc.format.none.fl_str_mv | 8 p application/pdf |
| dc.identifier.none.fl_str_mv | Van Lier, E, Meikle, A, Eriksson, H y Sahlin, L. Insulin-like growth factor-I (IGF-I) and thioredoxin are differentially expressed along the reproductive tract of the ewe during the oestrous cycle and after ovariectomy. Acta Veterinaria Scandinavica. [en línea] 2006, 1(5), 1-8 https://hdl.handle.net/20.500.12008/50679 10.1186/1751-0147-1-5 |
| dc.language.none.fl_str_mv | en eng |
| dc.relation.none.fl_str_mv | Acta Veterinaria Scandinavica, 2006, 1(5), 1-8 |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | OVINOS OVEJAS OVARIECTOMIA CICLO ESTRAL ESTEROIDES |
| dc.title.none.fl_str_mv | Insulin-like growth factor-I (IGF-I) and thioredoxin are differentially expressed along the reproductive tract of the ewe during the oestrous cycle and after ovariectomy |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Insulin-like growth factor-I (IGF-I) and thioredoxin are regulated by gonadal steroids in the female reproductive tract of many species. Oestradiol regulates IGF-I and thioredoxin mRNA levels in the reproductive tract of prepubertal lambs. The physiological status (different endocrine environment) may affect the sensitivity of the reproductive tract to oestradiol and progesterone. We studied the effects of different endocrine milieus (late-follicular and luteal phases of the oestrous cycle, and ovariectomy before or after puberty) on the expression of IGF-I, thioredoxin, oestrogen receptor α (ERα) and progesterone receptor (PR) in sheep. The mRNA levels were determined by a solution hybridisation technique. In the uterus the levels of ERα, PR and thioredoxin mRNA were higher in the late-follicular phase group than in the other three groups, and IGF-I mRNA was high during both the late-follicular and the luteal phases. In the cervix only PR mRNA was significantly higher in the ewes in the late-follicular phase than in the other groups. In the oviducts the levels of thioredoxin and ERα mRNA were highest in the ovariectomised adult ewes, and thioredoxin mRNA was higher than the levels found in the ewes in the late-follicular phase. The IGF-I mRNA levels in the oviduct did not differ between any of the groups. The transcripts of IGF-I, thioredoxin, ERα and PR, varied according to the physiological status and also along the female reproductive tract, suggesting that the regulation of the mRNA levels of these factors by the steroid environment is tissue specific. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_1fbe3c19fe588d1d500a262f4cbb7660 |
| identifier_str_mv | Van Lier, E, Meikle, A, Eriksson, H y Sahlin, L. Insulin-like growth factor-I (IGF-I) and thioredoxin are differentially expressed along the reproductive tract of the ewe during the oestrous cycle and after ovariectomy. Acta Veterinaria Scandinavica. [en línea] 2006, 1(5), 1-8 10.1186/1751-0147-1-5 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/50679 |
| publishDate | 2006 |
| publishDateSort | 2006 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| spelling | Insulin-like growth factor-I (IGF-I) and thioredoxin are differentially expressed along the reproductive tract of the ewe during the oestrous cycle and after ovariectomyVan Lier, ElizeMeikle, AnaEriksson, HåkanSahlin, LOVINOSOVEJASOVARIECTOMIACICLO ESTRALESTEROIDESInsulin-like growth factor-I (IGF-I) and thioredoxin are regulated by gonadal steroids in the female reproductive tract of many species. Oestradiol regulates IGF-I and thioredoxin mRNA levels in the reproductive tract of prepubertal lambs. The physiological status (different endocrine environment) may affect the sensitivity of the reproductive tract to oestradiol and progesterone. We studied the effects of different endocrine milieus (late-follicular and luteal phases of the oestrous cycle, and ovariectomy before or after puberty) on the expression of IGF-I, thioredoxin, oestrogen receptor α (ERα) and progesterone receptor (PR) in sheep. The mRNA levels were determined by a solution hybridisation technique. In the uterus the levels of ERα, PR and thioredoxin mRNA were higher in the late-follicular phase group than in the other three groups, and IGF-I mRNA was high during both the late-follicular and the luteal phases. In the cervix only PR mRNA was significantly higher in the ewes in the late-follicular phase than in the other groups. In the oviducts the levels of thioredoxin and ERα mRNA were highest in the ovariectomised adult ewes, and thioredoxin mRNA was higher than the levels found in the ewes in the late-follicular phase. The IGF-I mRNA levels in the oviduct did not differ between any of the groups. The transcripts of IGF-I, thioredoxin, ERα and PR, varied according to the physiological status and also along the female reproductive tract, suggesting that the regulation of the mRNA levels of these factors by the steroid environment is tissue specific.Van Lier Elize, Universidad de la República (Uruguay). Faculty of Agriculture. Animal and Forage Sciences DepartmentMeikle Ana, Universidad de la República (Uruguay). Veterinary Faculty. Department of Molecular and Cellular BiologyEriksson Håkan, Karolinska Institutet (Stockholm, Sweden). Department of Woman and Child Health. Division for Reproductive EndocrinologySahlin L, Karolinska Institutet (Stockholm, Sweden). Department of Woman and Child Health. Division for Reproductive Endocrinology2025-07-21T12:46:48Z2025-07-21T12:46:48Z2006Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion8 papplication/pdfVan Lier, E, Meikle, A, Eriksson, H y Sahlin, L. Insulin-like growth factor-I (IGF-I) and thioredoxin are differentially expressed along the reproductive tract of the ewe during the oestrous cycle and after ovariectomy. Acta Veterinaria Scandinavica. [en línea] 2006, 1(5), 1-8https://hdl.handle.net/20.500.12008/5067910.1186/1751-0147-1-5reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengActa Veterinaria Scandinavica, 2006, 1(5), 1-8Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)oai:colibri.udelar.edu.uy:20.500.12008/506792026-04-14T10:35:07Z |
| spellingShingle | Insulin-like growth factor-I (IGF-I) and thioredoxin are differentially expressed along the reproductive tract of the ewe during the oestrous cycle and after ovariectomy Van Lier, Elize OVINOS OVEJAS OVARIECTOMIA CICLO ESTRAL ESTEROIDES |
| status_str | publishedVersion |
| title | Insulin-like growth factor-I (IGF-I) and thioredoxin are differentially expressed along the reproductive tract of the ewe during the oestrous cycle and after ovariectomy |
| title_full | Insulin-like growth factor-I (IGF-I) and thioredoxin are differentially expressed along the reproductive tract of the ewe during the oestrous cycle and after ovariectomy |
| title_fullStr | Insulin-like growth factor-I (IGF-I) and thioredoxin are differentially expressed along the reproductive tract of the ewe during the oestrous cycle and after ovariectomy |
| title_full_unstemmed | Insulin-like growth factor-I (IGF-I) and thioredoxin are differentially expressed along the reproductive tract of the ewe during the oestrous cycle and after ovariectomy |
| title_short | Insulin-like growth factor-I (IGF-I) and thioredoxin are differentially expressed along the reproductive tract of the ewe during the oestrous cycle and after ovariectomy |
| title_sort | Insulin-like growth factor-I (IGF-I) and thioredoxin are differentially expressed along the reproductive tract of the ewe during the oestrous cycle and after ovariectomy |
| topic | OVINOS OVEJAS OVARIECTOMIA CICLO ESTRAL ESTEROIDES |
| url | https://hdl.handle.net/20.500.12008/50679 |