Is a computational model useful to understand the effect of deep brain stimulation in Parkinson's disease?
A growing number of computational models have been proposed over the last few years to help explain the therapeutic effect of deep brain stimulation (DBS) on motor disorders in Parkinson's disease (PD). However, none of these has been able to explain in a convincing manner the physiological mechanis...
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| Format: | article |
| Language: | English |
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2006
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| Online Access: | https://hdl.handle.net/20.500.12008/38750 |
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| _version_ | 1868889970940313600 |
|---|---|
| author | Pascual, Alejandro |
| author2 | Modolo, J Beuter, A |
| author2_role | author author |
| author_browse | Beuter, A Modolo, J Pascual, Alejandro |
| author_facet | Pascual, Alejandro Modolo, J Beuter, A |
| author_role | author |
| collection | COLIBRI |
| dc.creator.none.fl_str_mv | Pascual, Alejandro Modolo, J Beuter, A |
| dc.date.none.fl_str_mv | 2006 2023-08-01T20:33:36Z 2023-08-01T20:33:36Z 20230801 |
| dc.identifier.none.fl_str_mv | Pascual A, Modolo J, Beuter A. Is a computational model useful to understand the effect of deep brain stimulation in Parkinson's disease? Journal of Integrative Neuroscience, 2006, v.5, no. 4:541-59. doi: 10.1142/s021963520600132x. https://hdl.handle.net/20.500.12008/38750 |
| dc.language.none.fl_str_mv | en eng |
| dc.relation.none.fl_str_mv | Journal of Integrative Neuroscience, 2006, v. 5, no. 4 |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Deep brain stimulation Parkinson's disease Computational models Systems biology |
| dc.title.none.fl_str_mv | Is a computational model useful to understand the effect of deep brain stimulation in Parkinson's disease? |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | A growing number of computational models have been proposed over the last few years to help explain the therapeutic effect of deep brain stimulation (DBS) on motor disorders in Parkinson's disease (PD). However, none of these has been able to explain in a convincing manner the physiological mechanisms underlying DBS. Can these models really contribute to improving our understanding? The model by Rubin and Terman [31] represents one of the most comprehensive and biologically plausible models of DBS published recently. We examined the validity of the model, replicated its simulations and tested its robustness. While our simulations partially reproduced the results presented by Rubin and Terman [31], several issues were raised including the high complexity of the model in its non simplified form, the lack of robustness of the model with respect to small perturbations, the nonrealistic representation of the thalamus and the absence of time delays. Computational models are indeed necessary, but they may not be sufficient in their current forms to explain the effect of chronic electrical stimulation on the activity of the basal ganglia (BG) network in PD. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_199fe5f82d2fd18cbc82ce7dc0f7c19b |
| identifier_str_mv | Pascual A, Modolo J, Beuter A. Is a computational model useful to understand the effect of deep brain stimulation in Parkinson's disease? Journal of Integrative Neuroscience, 2006, v.5, no. 4:541-59. doi: 10.1142/s021963520600132x. |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/38750 |
| publishDate | 2006 |
| publishDateSort | 2006 |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| spelling | Is a computational model useful to understand the effect of deep brain stimulation in Parkinson's disease?Pascual, AlejandroModolo, JBeuter, ADeep brain stimulationParkinson's diseaseComputational modelsSystems biologyA growing number of computational models have been proposed over the last few years to help explain the therapeutic effect of deep brain stimulation (DBS) on motor disorders in Parkinson's disease (PD). However, none of these has been able to explain in a convincing manner the physiological mechanisms underlying DBS. Can these models really contribute to improving our understanding? The model by Rubin and Terman [31] represents one of the most comprehensive and biologically plausible models of DBS published recently. We examined the validity of the model, replicated its simulations and tested its robustness. While our simulations partially reproduced the results presented by Rubin and Terman [31], several issues were raised including the high complexity of the model in its non simplified form, the lack of robustness of the model with respect to small perturbations, the nonrealistic representation of the thalamus and the absence of time delays. Computational models are indeed necessary, but they may not be sufficient in their current forms to explain the effect of chronic electrical stimulation on the activity of the basal ganglia (BG) network in PD.2023-08-01T20:33:36Z2023-08-01T20:33:36Z200620230801Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPascual A, Modolo J, Beuter A. Is a computational model useful to understand the effect of deep brain stimulation in Parkinson's disease? Journal of Integrative Neuroscience, 2006, v.5, no. 4:541-59. doi: 10.1142/s021963520600132x.https://hdl.handle.net/20.500.12008/38750reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengJournal of Integrative Neuroscience, 2006, v. 5, no. 4Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad De La República. (Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)oai:colibri.udelar.edu.uy:20.500.12008/387502026-04-14T10:15:33Z |
| spellingShingle | Is a computational model useful to understand the effect of deep brain stimulation in Parkinson's disease? Pascual, Alejandro Deep brain stimulation Parkinson's disease Computational models Systems biology |
| status_str | publishedVersion |
| title | Is a computational model useful to understand the effect of deep brain stimulation in Parkinson's disease? |
| title_full | Is a computational model useful to understand the effect of deep brain stimulation in Parkinson's disease? |
| title_fullStr | Is a computational model useful to understand the effect of deep brain stimulation in Parkinson's disease? |
| title_full_unstemmed | Is a computational model useful to understand the effect of deep brain stimulation in Parkinson's disease? |
| title_short | Is a computational model useful to understand the effect of deep brain stimulation in Parkinson's disease? |
| title_sort | Is a computational model useful to understand the effect of deep brain stimulation in Parkinson's disease? |
| topic | Deep brain stimulation Parkinson's disease Computational models Systems biology |
| url | https://hdl.handle.net/20.500.12008/38750 |