Nanoparticulate architecture of protein-based artificial viruses is supported by protein DNA interactions

Aim & Methods: We have produced two chimerical peptides of 10.2 kDa, each contain four biologically active domains, which act as building blocks of protein-based nonviral vehicles for gene therapy. In solution, these peptides tend to aggregate as amorphous clusters of more than 1000 nm, while the pr...

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Bibliographic Details

Main Author:	Domingo-Espín, Joan (author)
Other Authors:	Vazquez, Esther (author), Ganz, Javier (author), Conchillo, Oscar (author), García-Fruitós, Elena (author), Cedano, Juan (author), Unzueta, Ugutz (author), Petegnief, Valérie (author), Gonzlez-Montalbán, Nuria (author), Planas, Anna M. (author), Daura, Xavier (author), Peluffo, Hugo (author), Ferrer-Miralles, Neus (author), Villaverde, Antonio (author)
Format:	article
Language:	English
Published:	2011
Subjects:	DNA–protein interaction Terapia Génica Ciencias Naturales y Exactas Ciencias Biológicas Genética y Herencia
Online Access:	http://hdl.handle.net/20.500.12381/134 http://dx.doi.org/10.2217/nnm.11.28
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