Hepatitis E and chronic liver damage in apparently immunocompetent individuals: Now what?
Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis worldwide, accounting for 20 million infections per year and 70,000 deaths. In developed regions, sporadic locally acquired infections are most commonly caused by HEV3, and in this setting Hepatitis E is mainly asymptomatic. H...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | article |
| Language: | English |
| Published: |
2019
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/20.500.12008/27210 |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1868889959477280768 |
|---|---|
| author | Arbiza, Juan |
| author2 | Mirazo, Santiago |
| author2_role | author |
| author_browse | Arbiza, Juan Mirazo, Santiago |
| author_facet | Arbiza, Juan Mirazo, Santiago |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Arbiza Juan, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Mirazo Santiago, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. |
| dc.creator.none.fl_str_mv | Arbiza, Juan Mirazo, Santiago |
| dc.date.none.fl_str_mv | 2019 2021-04-23T13:02:20Z 2021-04-23T13:02:20Z |
| dc.format.none.fl_str_mv | 2 h. application/pdf |
| dc.identifier.none.fl_str_mv | Arbiza, J y Mirazo, S. "Hepatitis E and chronic liver damage in apparently immunocompetent individuals: Now what?". Annals of Hepatology. [en línea] 2019.18(4):539-540 2 h. DOI: 10.1016/j.aohep.2019.05.002 1665-2681 https://hdl.handle.net/20.500.12008/27210 10.1016/j.aohep.2019.05.002 |
| dc.language.none.fl_str_mv | en eng |
| dc.publisher.none.fl_str_mv | Fundación Clínica Médica Sur |
| dc.relation.none.fl_str_mv | Annals of Hepatology, 2019, 18(4): 539-540 |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Chronic liver disease Non-identified infectious etiological agent (NIIEA) Hepatitis E |
| dc.title.none.fl_str_mv | Hepatitis E and chronic liver damage in apparently immunocompetent individuals: Now what? |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis worldwide, accounting for 20 million infections per year and 70,000 deaths. In developed regions, sporadic locally acquired infections are most commonly caused by HEV3, and in this setting Hepatitis E is mainly asymptomatic. However, certain group of patients HEV infection may present as a fulminant disease or progressive fibrosis. Chronic HEV infection can occur in immunocompromised individuals, including transplant recipients. A high proportion of solid-organ transplant recipients exposed to HEV are at risk of developing a chronic infection, frequently associated to extrahepatic manifestations. However, clinical phenotype of sporadic cases of HEV infection is still poorly characterized. A recent work, focused on the retrospective study of HEV as a causative agent of viral hepatitis in adults form Mexico, pose novel challenges to understanding the HEV threat to human health. Main findings are brought into discussion herein, in light of the current knowledge concerning viral pathogenesis and host–pathogen interaction. The role of HEV infection in the development of chronic liver disease is also discussed. Hepatitis E is a cause of mortality and morbidity which negatively impacts the prognosis of patients with chronic liver disease. Recognition of HEV infection must be improved, by increasing awareness and knowledge of the clinical phenotype of the disease. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_11d2d5de0e1a2bdfca2632df948781fa |
| identifier_str_mv | Arbiza, J y Mirazo, S. "Hepatitis E and chronic liver damage in apparently immunocompetent individuals: Now what?". Annals of Hepatology. [en línea] 2019.18(4):539-540 2 h. DOI: 10.1016/j.aohep.2019.05.002 1665-2681 10.1016/j.aohep.2019.05.002 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/27210 |
| publishDate | 2019 |
| publishDateSort | 2019 |
| publisher.none.fl_str_mv | Fundación Clínica Médica Sur |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| spelling | Hepatitis E and chronic liver damage in apparently immunocompetent individuals: Now what?Arbiza, JuanMirazo, SantiagoChronic liver diseaseNon-identified infectious etiological agent (NIIEA)Hepatitis EHepatitis E virus (HEV) is the most common cause of acute viral hepatitis worldwide, accounting for 20 million infections per year and 70,000 deaths. In developed regions, sporadic locally acquired infections are most commonly caused by HEV3, and in this setting Hepatitis E is mainly asymptomatic. However, certain group of patients HEV infection may present as a fulminant disease or progressive fibrosis. Chronic HEV infection can occur in immunocompromised individuals, including transplant recipients. A high proportion of solid-organ transplant recipients exposed to HEV are at risk of developing a chronic infection, frequently associated to extrahepatic manifestations. However, clinical phenotype of sporadic cases of HEV infection is still poorly characterized. A recent work, focused on the retrospective study of HEV as a causative agent of viral hepatitis in adults form Mexico, pose novel challenges to understanding the HEV threat to human health. Main findings are brought into discussion herein, in light of the current knowledge concerning viral pathogenesis and host–pathogen interaction. The role of HEV infection in the development of chronic liver disease is also discussed. Hepatitis E is a cause of mortality and morbidity which negatively impacts the prognosis of patients with chronic liver disease. Recognition of HEV infection must be improved, by increasing awareness and knowledge of the clinical phenotype of the disease.Fundación Clínica Médica SurArbiza Juan, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Mirazo Santiago, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica.2021-04-23T13:02:20Z2021-04-23T13:02:20Z2019Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion2 h.application/pdfArbiza, J y Mirazo, S. "Hepatitis E and chronic liver damage in apparently immunocompetent individuals: Now what?". Annals of Hepatology. [en línea] 2019.18(4):539-540 2 h. DOI: 10.1016/j.aohep.2019.05.0021665-2681https://hdl.handle.net/20.500.12008/2721010.1016/j.aohep.2019.05.002reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengAnnals of Hepatology, 2019, 18(4): 539-540Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)oai:colibri.udelar.edu.uy:20.500.12008/272102026-04-14T10:09:36Z |
| spellingShingle | Hepatitis E and chronic liver damage in apparently immunocompetent individuals: Now what? Arbiza, Juan Chronic liver disease Non-identified infectious etiological agent (NIIEA) Hepatitis E |
| status_str | publishedVersion |
| title | Hepatitis E and chronic liver damage in apparently immunocompetent individuals: Now what? |
| title_full | Hepatitis E and chronic liver damage in apparently immunocompetent individuals: Now what? |
| title_fullStr | Hepatitis E and chronic liver damage in apparently immunocompetent individuals: Now what? |
| title_full_unstemmed | Hepatitis E and chronic liver damage in apparently immunocompetent individuals: Now what? |
| title_short | Hepatitis E and chronic liver damage in apparently immunocompetent individuals: Now what? |
| title_sort | Hepatitis E and chronic liver damage in apparently immunocompetent individuals: Now what? |
| topic | Chronic liver disease Non-identified infectious etiological agent (NIIEA) Hepatitis E |
| url | https://hdl.handle.net/20.500.12008/27210 |