Serological evidence of human infection with Coxiella burnetii after occupational exposure to aborting cattle.
Abstract:Cattle are broadly deemed a source of Coxiella burnetii; however, evidence reinforcing their role in human infection is scarce. Most published human Q fever outbreaks relate to exposure to small ruminants, notably goats. Anti-phase II C. burnetii IgG and IgM were measured by indirect fluore...
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2021
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| _version_ | 1868889954028879872 |
|---|---|
| author | RABAZA, A. |
| author2 | GIANNITTI, F. FRAGA, M. MACÍAS-RIOSECO, M. CORBELLINI, L.G. RIET-CORREA, F. HIRIGOYEN, D. TURNER, K.M.E. EISLER, ,M.C. |
| author2_role | author author author author author author author author |
| author_browse | CORBELLINI, L.G. EISLER, ,M.C. FRAGA, M. GIANNITTI, F. HIRIGOYEN, D. MACÍAS-RIOSECO, M. RABAZA, A. RIET-CORREA, F. TURNER, K.M.E. |
| author_facet | RABAZA, A. GIANNITTI, F. FRAGA, M. MACÍAS-RIOSECO, M. CORBELLINI, L.G. RIET-CORREA, F. HIRIGOYEN, D. TURNER, K.M.E. EISLER, ,M.C. |
| author_role | author |
| collection | AINFO |
| dc.creator.none.fl_str_mv | RABAZA, A. GIANNITTI, F. FRAGA, M. MACÍAS-RIOSECO, M. CORBELLINI, L.G. RIET-CORREA, F. HIRIGOYEN, D. TURNER, K.M.E. EISLER, ,M.C. |
| dc.date.none.fl_str_mv | 2021 2022-10-21T01:57:52Z 2022-10-21T01:57:52Z 2022-10-21T01:57:52Z |
| dc.identifier.none.fl_str_mv | https://ainfo.inia.uy/consulta/busca?b=pc&id=62524&biblioteca=vazio&busca=62524&qFacets=62524 |
| dc.language.none.fl_str_mv | en eng |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Acceso abierto |
| dc.source.none.fl_str_mv | reponame:AINFO instname:Instituto Nacional de Investigación Agropecuaria instacron:Instituto Nacional de Investigación Agropecuaria |
| dc.subject.none.fl_str_mv | PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL PLATAFORMA DE SALUD ANIMAL Coxiellosis Indirect fluorescent antibody test (IFAT) Q fever Zoonosis Occupational hazard INFECCION HUMANA |
| dc.title.none.fl_str_mv | Serological evidence of human infection with Coxiella burnetii after occupational exposure to aborting cattle. |
| dc.type.none.fl_str_mv | Article PublishedVersion info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Abstract:Cattle are broadly deemed a source of Coxiella burnetii; however, evidence reinforcing their role in human infection is scarce. Most published human Q fever outbreaks relate to exposure to small ruminants, notably goats. Anti-phase II C. burnetii IgG and IgM were measured by indirect fluorescent antibody tests in 27 farm and veterinary diagnostic laboratory workers to ascertain whether occupational exposure to cattle aborting due to C. burnetii was the probable source of exposure. Four serological profiles were identified on the basis of anti-phase II IgG and IgM titres. Profile 1, characterised by high IgM levels and concurrent, lower IgG titres (3/27; 11.1%); Profile 2, with both isotypes with IgG titres higher than IgM (2/27; 7.4%); Profile 3 with only IgG phase II (5/27; 18.5%); and Profile 4, in which neither IgM nor IgG were detected (17/27; 63.0%). Profiles 1 and 2 are suggestive of recent C. burnetii exposure, most likely 2.5?4.5 months before testing and, hence, during the window of exposure to the bovine abortions. Profile 3 suggested C. burnetii exposure that most likely predated the window of exposure to aborting cattle, while Profile 4 represented seronegative individuals and, hence, likely uninfected. This study formally linked human Q fever to exposure to C. burnetii infected cattle as a specific occupational hazard for farm and laboratory workers handling bovine aborted material. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_0ea244a3e2ff9b941d3262c26f05cfbc |
| instacron_str | Instituto Nacional de Investigación Agropecuaria |
| institution | Instituto Nacional de Investigación Agropecuaria |
| instname_str | Instituto Nacional de Investigación Agropecuaria |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:redi.anii.org.uy:20.500.12381/2015 |
| publishDate | 2021 |
| publishDateSort | 2021 |
| reponame_str | AINFO |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Acceso abierto |
| spelling | Serological evidence of human infection with Coxiella burnetii after occupational exposure to aborting cattle.RABAZA, A.GIANNITTI, F.FRAGA, M.MACÍAS-RIOSECO, M.CORBELLINI, L.G.RIET-CORREA, F.HIRIGOYEN, D.TURNER, K.M.E.EISLER, ,M.C.PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMALPLATAFORMA DE SALUD ANIMALCoxiellosisIndirect fluorescent antibody test (IFAT)Q feverZoonosisOccupational hazardINFECCION HUMANAAbstract:Cattle are broadly deemed a source of Coxiella burnetii; however, evidence reinforcing their role in human infection is scarce. Most published human Q fever outbreaks relate to exposure to small ruminants, notably goats. Anti-phase II C. burnetii IgG and IgM were measured by indirect fluorescent antibody tests in 27 farm and veterinary diagnostic laboratory workers to ascertain whether occupational exposure to cattle aborting due to C. burnetii was the probable source of exposure. Four serological profiles were identified on the basis of anti-phase II IgG and IgM titres. Profile 1, characterised by high IgM levels and concurrent, lower IgG titres (3/27; 11.1%); Profile 2, with both isotypes with IgG titres higher than IgM (2/27; 7.4%); Profile 3 with only IgG phase II (5/27; 18.5%); and Profile 4, in which neither IgM nor IgG were detected (17/27; 63.0%). Profiles 1 and 2 are suggestive of recent C. burnetii exposure, most likely 2.5?4.5 months before testing and, hence, during the window of exposure to the bovine abortions. Profile 3 suggested C. burnetii exposure that most likely predated the window of exposure to aborting cattle, while Profile 4 represented seronegative individuals and, hence, likely uninfected. This study formally linked human Q fever to exposure to C. burnetii infected cattle as a specific occupational hazard for farm and laboratory workers handling bovine aborted material.2022-10-21T01:57:52Z2022-10-21T01:57:52Z20212022-10-21T01:57:52ZArticlePublishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://ainfo.inia.uy/consulta/busca?b=pc&id=62524&biblioteca=vazio&busca=62524&qFacets=62524reponame:AINFOinstname:Instituto Nacional de Investigación Agropecuariainstacron:Instituto Nacional de Investigación Agropecuariaenenginfo:eu-repo/semantics/openAccessAcceso abiertooai:redi.anii.org.uy:20.500.12381/20152026-02-10T17:37:10Z |
| spellingShingle | Serological evidence of human infection with Coxiella burnetii after occupational exposure to aborting cattle. RABAZA, A. PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL PLATAFORMA DE SALUD ANIMAL Coxiellosis Indirect fluorescent antibody test (IFAT) Q fever Zoonosis Occupational hazard INFECCION HUMANA |
| status_str | publishedVersion |
| title | Serological evidence of human infection with Coxiella burnetii after occupational exposure to aborting cattle. |
| title_full | Serological evidence of human infection with Coxiella burnetii after occupational exposure to aborting cattle. |
| title_fullStr | Serological evidence of human infection with Coxiella burnetii after occupational exposure to aborting cattle. |
| title_full_unstemmed | Serological evidence of human infection with Coxiella burnetii after occupational exposure to aborting cattle. |
| title_short | Serological evidence of human infection with Coxiella burnetii after occupational exposure to aborting cattle. |
| title_sort | Serological evidence of human infection with Coxiella burnetii after occupational exposure to aborting cattle. |
| topic | PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL PLATAFORMA DE SALUD ANIMAL Coxiellosis Indirect fluorescent antibody test (IFAT) Q fever Zoonosis Occupational hazard INFECCION HUMANA |
| url | https://ainfo.inia.uy/consulta/busca?b=pc&id=62524&biblioteca=vazio&busca=62524&qFacets=62524 |