Bioinformatic analysis of a novel Echinococcus granulosus nuclear receptor with two DNA binding domains
Nuclear receptors are ligand-activated transcription factors capable of regulating the expression of complex gene networks. The family includes seven subfamilies of proteins with a wide phylogenetic distribution. A novel subfamily with two DNA-binding domains (2DBDs) has been reported in Schistosoma...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , , |
| Format: | article |
| Language: | English |
| Published: |
2019
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/20.500.12008/28349 |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1868889952246300672 |
|---|---|
| author | Alvite, Gabriela |
| author2 | Riera Nikicer, Ximena Cancela Bruno, Saira Paulino, Margot Esteves, Adriana |
| author2_role | author author author author |
| author_browse | Alvite, Gabriela Cancela Bruno, Saira Esteves, Adriana Paulino, Margot Riera Nikicer, Ximena |
| author_facet | Alvite, Gabriela Riera Nikicer, Ximena Cancela Bruno, Saira Paulino, Margot Esteves, Adriana |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Alvite Gabriela, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Riera Nikicer Ximena, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Cancela Bruno Saira, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física. Paulino Margot, Universidad de la República (Uruguay). Facultad de Química. Esteves Brescia Adriana, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. |
| dc.creator.none.fl_str_mv | Alvite, Gabriela Riera Nikicer, Ximena Cancela Bruno, Saira Paulino, Margot Esteves, Adriana |
| dc.date.none.fl_str_mv | 2019 2021-06-24T15:41:59Z 2021-06-24T15:41:59Z |
| dc.format.none.fl_str_mv | 16 h. application/pdf |
| dc.identifier.none.fl_str_mv | Alvite, G, Riera, X, Cancela Bruno, S, y otros "Bioinformatic analysis of a novel Echinococcus granulosus nuclear receptor with two DNA binding domains". PLoS ONE. [en línea] 2019, 14(11): e0224703. 16 h. DOI: 10.1371/journal.pone.0224703 1932-6203 https://hdl.handle.net/20.500.12008/28349 10.1371/journal.pone.0224703 |
| dc.language.none.fl_str_mv | en eng |
| dc.publisher.none.fl_str_mv | Public Library of Science |
| dc.relation.none.fl_str_mv | PLoS ONE, 2019, 14(11): e0224703 |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | Echinococcus granulosus Nuclear receptor Bioinformatics analysis Eg2DBDα |
| dc.title.none.fl_str_mv | Bioinformatic analysis of a novel Echinococcus granulosus nuclear receptor with two DNA binding domains |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Nuclear receptors are ligand-activated transcription factors capable of regulating the expression of complex gene networks. The family includes seven subfamilies of proteins with a wide phylogenetic distribution. A novel subfamily with two DNA-binding domains (2DBDs) has been reported in Schistosoma mansoni (Platyhelminth, Trematoda). This work describes the cDNA cloning and bioinformatics analysis of Eg2DBDα, a 2DBD nuclear receptor isoform from the parasite Echinococcus granulosus (Platyhelminth, Cestoda). The Eg2DBDα gene coding domain structure was analysed. Although two additional 2DBD nuclear receptors are reported in the parasite database GeneDB, they are unlikely to be expressed in the larval stage. Phylogenetic relationships between these atypical proteins from different cestodes are also analysed including S. mansoni 2DBD nuclear receptors. The presence of two DNA binding domains confers particular interest to these nuclear receptors, not only concerning their function but to the development of new antihelminthic drugs. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_0d3a60fe2b9fc2c7b6c6e05e8dbd6683 |
| identifier_str_mv | Alvite, G, Riera, X, Cancela Bruno, S, y otros "Bioinformatic analysis of a novel Echinococcus granulosus nuclear receptor with two DNA binding domains". PLoS ONE. [en línea] 2019, 14(11): e0224703. 16 h. DOI: 10.1371/journal.pone.0224703 1932-6203 10.1371/journal.pone.0224703 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/28349 |
| publishDate | 2019 |
| publishDateSort | 2019 |
| publisher.none.fl_str_mv | Public Library of Science |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Bioinformatic analysis of a novel Echinococcus granulosus nuclear receptor with two DNA binding domainsAlvite, GabrielaRiera Nikicer, XimenaCancela Bruno, SairaPaulino, MargotEsteves, AdrianaEchinococcus granulosusNuclear receptorBioinformatics analysisEg2DBDαNuclear receptors are ligand-activated transcription factors capable of regulating the expression of complex gene networks. The family includes seven subfamilies of proteins with a wide phylogenetic distribution. A novel subfamily with two DNA-binding domains (2DBDs) has been reported in Schistosoma mansoni (Platyhelminth, Trematoda). This work describes the cDNA cloning and bioinformatics analysis of Eg2DBDα, a 2DBD nuclear receptor isoform from the parasite Echinococcus granulosus (Platyhelminth, Cestoda). The Eg2DBDα gene coding domain structure was analysed. Although two additional 2DBD nuclear receptors are reported in the parasite database GeneDB, they are unlikely to be expressed in the larval stage. Phylogenetic relationships between these atypical proteins from different cestodes are also analysed including S. mansoni 2DBD nuclear receptors. The presence of two DNA binding domains confers particular interest to these nuclear receptors, not only concerning their function but to the development of new antihelminthic drugs.Public Library of ScienceAlvite Gabriela, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Riera Nikicer Ximena, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.Cancela Bruno Saira, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Física.Paulino Margot, Universidad de la República (Uruguay). Facultad de Química.Esteves Brescia Adriana, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.2021-06-24T15:41:59Z2021-06-24T15:41:59Z2019Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion16 h.application/pdfAlvite, G, Riera, X, Cancela Bruno, S, y otros "Bioinformatic analysis of a novel Echinococcus granulosus nuclear receptor with two DNA binding domains". PLoS ONE. [en línea] 2019, 14(11): e0224703. 16 h. DOI: 10.1371/journal.pone.02247031932-6203https://hdl.handle.net/20.500.12008/2834910.1371/journal.pone.0224703reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengPLoS ONE, 2019, 14(11): e0224703Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)oai:colibri.udelar.edu.uy:20.500.12008/283492026-04-14T10:09:39Z |
| spellingShingle | Bioinformatic analysis of a novel Echinococcus granulosus nuclear receptor with two DNA binding domains Alvite, Gabriela Echinococcus granulosus Nuclear receptor Bioinformatics analysis Eg2DBDα |
| status_str | publishedVersion |
| title | Bioinformatic analysis of a novel Echinococcus granulosus nuclear receptor with two DNA binding domains |
| title_full | Bioinformatic analysis of a novel Echinococcus granulosus nuclear receptor with two DNA binding domains |
| title_fullStr | Bioinformatic analysis of a novel Echinococcus granulosus nuclear receptor with two DNA binding domains |
| title_full_unstemmed | Bioinformatic analysis of a novel Echinococcus granulosus nuclear receptor with two DNA binding domains |
| title_short | Bioinformatic analysis of a novel Echinococcus granulosus nuclear receptor with two DNA binding domains |
| title_sort | Bioinformatic analysis of a novel Echinococcus granulosus nuclear receptor with two DNA binding domains |
| topic | Echinococcus granulosus Nuclear receptor Bioinformatics analysis Eg2DBDα |
| url | https://hdl.handle.net/20.500.12008/28349 |