First detection and origin of multi-drug resistant Klebsiella pneumoniae ST15 harboring OXA-48 in South America
Objectives: The emergence and spread of carbapenem resistant clones is of major concern for global health. This study aimed to characterize the first detected Klebsiella pneumoniae ST15 harboring the epi- demic carbapenemase OXA-48 in South America. Methods: During a routine colonization screening w...
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| প্রধান লেখক: | |
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| অন্যান্য লেখক: | , , , , , |
| বিন্যাস: | article |
| ভাষা: | ইংরেজি |
| প্রকাশিত: |
2022
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | https://hdl.handle.net/20.500.12008/38461 |
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| _version_ | 1868889950455332864 |
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| author | Salazar González, María Cecilia |
| author2 | Antelo Gutiérrez, Verónica Beatriz Vieytes, Mariela Dávila, Cristina Grill, Fabio Galiana, Antonio Iraola, Gregorio |
| author2_role | author author author author author author |
| author_browse | Antelo Gutiérrez, Verónica Beatriz Dávila, Cristina Galiana, Antonio Grill, Fabio Iraola, Gregorio Salazar González, María Cecilia Vieytes, Mariela |
| author_facet | Salazar González, María Cecilia Antelo Gutiérrez, Verónica Beatriz Vieytes, Mariela Dávila, Cristina Grill, Fabio Galiana, Antonio Iraola, Gregorio |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Salazar González María Cecilia, Instituto Pasteur (Montevideo). Antelo Gutiérrez Verónica Beatriz, Instituto Pasteur (Montevideo). Vieytes Mariela Dávila Cristina Grill Fabio Galiana Antonio Iraola Gregorio, Instituto Pasteur (Montevideo). |
| dc.creator.none.fl_str_mv | Salazar González, María Cecilia Antelo Gutiérrez, Verónica Beatriz Vieytes, Mariela Dávila, Cristina Grill, Fabio Galiana, Antonio Iraola, Gregorio |
| dc.date.none.fl_str_mv | 2022 2023-07-27T13:01:58Z 2023-07-27T13:01:58Z |
| dc.format.none.fl_str_mv | 5 h. application/pdf |
| dc.identifier.none.fl_str_mv | Salazar González, M, Antelo Gutiérrez, V, Vieytes, M, [y otros autores]. "First detection and origin of multi-drug resistant Klebsiella pneumoniae ST15 harboring OXA-48 in South America". Journal of Global Antimicrobial Resistance. [en línea] 2022, 30: 480-484. 5 h. DOI: 10.1016/j.jgar.2022.08.005 2213-7165 https://hdl.handle.net/20.500.12008/38461 10.1016/j.jgar.2022.08.005 |
| dc.language.none.fl_str_mv | en_US eng |
| dc.publisher.none.fl_str_mv | Elsevier Ltd |
| dc.relation.none.fl_str_mv | Journal of Global Antimicrobial Resistance, 2022, 30: 480-484. |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | OXA-48 Carbapenem resistance Klebsiella pneumonia Multi-drug resistance Whole-genome sequencing |
| dc.title.none.fl_str_mv | First detection and origin of multi-drug resistant Klebsiella pneumoniae ST15 harboring OXA-48 in South America |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Objectives: The emergence and spread of carbapenem resistant clones is of major concern for global health. This study aimed to characterize the first detected Klebsiella pneumoniae ST15 harboring the epi- demic carbapenemase OXA-48 in South America. Methods: During a routine colonization screening with carbapenem-resistant bacteria, one K. pneumoniae strain (CGHM01) was isolated from the urine of a hospitalized patient suffering from a neurodegenera- tive disease in Uruguay. We used long-read whole-genome sequencing and a phylogenomic approach to characterize the emergence of K. pneumoniae CGHM01. Results: K. pneumoniae CGHM01 is a multi-drug resistant strain carrying an IncL/M plasmid that encodes the carbapenemase gene bla OXA-48 within the Tn1999.2 transposon. Also, it carries an IncR plasmid har- boring a class I integron with an array of antibiotic resistance genes including the extended-spectrum beta-lactamase bla CTX-M-15 . Two copies of bla CTX-M-15 were also inserted in different positions of the chro- mosome. CGHM01 belongs to a ST15 sublineage that likely originated in continental Spain around 2012. Conclusions: The asymptomatic carriage of this strain in the urinary tract warns of difficulties for detec- tion and reporting of emerging carbapenem-resistant clones in new geographic areas where these are not endemic. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_0c4bc29df24f0bd03d4ea332e70b3eed |
| identifier_str_mv | Salazar González, M, Antelo Gutiérrez, V, Vieytes, M, [y otros autores]. "First detection and origin of multi-drug resistant Klebsiella pneumoniae ST15 harboring OXA-48 in South America". Journal of Global Antimicrobial Resistance. [en línea] 2022, 30: 480-484. 5 h. DOI: 10.1016/j.jgar.2022.08.005 2213-7165 10.1016/j.jgar.2022.08.005 |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en_US |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/38461 |
| publishDate | 2022 |
| publishDateSort | 2022 |
| publisher.none.fl_str_mv | Elsevier Ltd |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) |
| spelling | First detection and origin of multi-drug resistant Klebsiella pneumoniae ST15 harboring OXA-48 in South AmericaSalazar González, María CeciliaAntelo Gutiérrez, Verónica BeatrizVieytes, MarielaDávila, CristinaGrill, FabioGaliana, AntonioIraola, GregorioOXA-48Carbapenem resistanceKlebsiella pneumoniaMulti-drug resistanceWhole-genome sequencingObjectives: The emergence and spread of carbapenem resistant clones is of major concern for global health. This study aimed to characterize the first detected Klebsiella pneumoniae ST15 harboring the epi- demic carbapenemase OXA-48 in South America. Methods: During a routine colonization screening with carbapenem-resistant bacteria, one K. pneumoniae strain (CGHM01) was isolated from the urine of a hospitalized patient suffering from a neurodegenera- tive disease in Uruguay. We used long-read whole-genome sequencing and a phylogenomic approach to characterize the emergence of K. pneumoniae CGHM01. Results: K. pneumoniae CGHM01 is a multi-drug resistant strain carrying an IncL/M plasmid that encodes the carbapenemase gene bla OXA-48 within the Tn1999.2 transposon. Also, it carries an IncR plasmid har- boring a class I integron with an array of antibiotic resistance genes including the extended-spectrum beta-lactamase bla CTX-M-15 . Two copies of bla CTX-M-15 were also inserted in different positions of the chro- mosome. CGHM01 belongs to a ST15 sublineage that likely originated in continental Spain around 2012. Conclusions: The asymptomatic carriage of this strain in the urinary tract warns of difficulties for detec- tion and reporting of emerging carbapenem-resistant clones in new geographic areas where these are not endemic.Elsevier LtdSalazar González María Cecilia, Instituto Pasteur (Montevideo).Antelo Gutiérrez Verónica Beatriz, Instituto Pasteur (Montevideo).Vieytes MarielaDávila CristinaGrill FabioGaliana AntonioIraola Gregorio, Instituto Pasteur (Montevideo).2023-07-27T13:01:58Z2023-07-27T13:01:58Z2022Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion5 h.application/pdfSalazar González, M, Antelo Gutiérrez, V, Vieytes, M, [y otros autores]. "First detection and origin of multi-drug resistant Klebsiella pneumoniae ST15 harboring OXA-48 in South America". Journal of Global Antimicrobial Resistance. [en línea] 2022, 30: 480-484. 5 h. DOI: 10.1016/j.jgar.2022.08.0052213-7165https://hdl.handle.net/20.500.12008/3846110.1016/j.jgar.2022.08.005reponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la Repúblicaen_USengJournal of Global Antimicrobial Resistance, 2022, 30: 480-484.Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)oai:colibri.udelar.edu.uy:20.500.12008/384612026-04-14T10:10:09Z |
| spellingShingle | First detection and origin of multi-drug resistant Klebsiella pneumoniae ST15 harboring OXA-48 in South America Salazar González, María Cecilia OXA-48 Carbapenem resistance Klebsiella pneumonia Multi-drug resistance Whole-genome sequencing |
| status_str | publishedVersion |
| title | First detection and origin of multi-drug resistant Klebsiella pneumoniae ST15 harboring OXA-48 in South America |
| title_full | First detection and origin of multi-drug resistant Klebsiella pneumoniae ST15 harboring OXA-48 in South America |
| title_fullStr | First detection and origin of multi-drug resistant Klebsiella pneumoniae ST15 harboring OXA-48 in South America |
| title_full_unstemmed | First detection and origin of multi-drug resistant Klebsiella pneumoniae ST15 harboring OXA-48 in South America |
| title_short | First detection and origin of multi-drug resistant Klebsiella pneumoniae ST15 harboring OXA-48 in South America |
| title_sort | First detection and origin of multi-drug resistant Klebsiella pneumoniae ST15 harboring OXA-48 in South America |
| topic | OXA-48 Carbapenem resistance Klebsiella pneumonia Multi-drug resistance Whole-genome sequencing |
| url | https://hdl.handle.net/20.500.12008/38461 |