Reciprocal regulation of acetyl-CoA carboxylase 1 and senescence in human fibroblasts involves oxidant mediated p38 MAPK activation

We sought to explore the fate of the fatty acid synthesis pathway in human fibroblasts exposed to DNA damaging agents capable of inducing senescence, a state of irreversible growth arrest. Induction of premature senescence by doxorubicin or hydrogen peroxide led to a decrease in protein and mRNA lev...

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Bibliographic Details

Main Author:	Marmisolle, Inés (author)
Other Authors:	Martínez, Jennyfer (author), Jie, Liu (author), Mastrogiovanni, Mauricio (author), Fergusson, María M. (author), Rovira, Ilsa I. (author), Castro, Laura (author), Trostchansky, Andrés (author), Moreno, María (author), Liu, Cao (author), Finkel, Toren (author), Quijano, Celia (author)
Format:	article
Language:	English
Published:	2017
Subjects:	Lipid synthesis Acetyl-CoA carboxylase 1 Cellular senescence DNA damage response Reactive oxygen species (ROS) p38 MAPK ACETIL-CoA CARBOXILASA SENESCENCIA CELULAR FIBROBLASTOS REPARACIÓN DEL ADN ESPECIES REACTIVAS DE OXÍGENO PROTEÍNAS QUINASAS p38 ACTIVADAS POR MITÓGENOS
Online Access:	https://hdl.handle.net/20.500.12008/51385
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