Genome-wide chromatin interaction map for Trypanosoma cruzi
Trypanosomes are eukaryotic, unicellular parasites, such as Trypanosoma brucei, which causes sleeping sickness, and Trypanosoma cruzi, which causes Chagas disease. Genomes of these parasites comprise core regions and species-specific disruptive regions that encode multigene families of surface glyco...
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| Beste egile batzuk: | , , |
| Formatua: | article |
| Hizkuntza: | ingelesa |
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2023
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| Sarrera elektronikoa: | https://hdl.handle.net/20.500.12008/52593 |
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| _version_ | 1868889922669117440 |
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| author | Díaz-Viraqué, Florencia |
| author2 | Chiribao, María Laura Libisch, María Gabriela Robello, Carlos |
| author2_role | author author author |
| author_browse | Chiribao, María Laura Díaz-Viraqué, Florencia Libisch, María Gabriela Robello, Carlos |
| author_facet | Díaz-Viraqué, Florencia Chiribao, María Laura Libisch, María Gabriela Robello, Carlos |
| author_role | author |
| collection | COLIBRI |
| dc.contributor.none.fl_str_mv | Díaz-Viraqué Florencia, Institut Pasteur de Montevideo (Uruguay) Chiribao María Laura, Universidad de la República (Uruguay). Facultad de Medicina Libisch María Gabriela, Institut Pasteur de Montevideo (Uruguay) Robello Carlos, Universidad de la República (Uruguay). Facultad de Medicina |
| dc.creator.none.fl_str_mv | Díaz-Viraqué, Florencia Chiribao, María Laura Libisch, María Gabriela Robello, Carlos |
| dc.date.none.fl_str_mv | 2023 2025-11-21T17:47:23Z 2025-11-21T17:47:23Z |
| dc.format.none.fl_str_mv | 19 p. application/pdf |
| dc.identifier.none.fl_str_mv | Díaz-Viraqué F, Chiribao M, Libisch M y otros. Genome-wide chromatin interaction map for Trypanosoma cruzi. Nature Microbiology [en línea]. 2023;8 (11):2103-2114 2058-5276 https://hdl.handle.net/20.500.12008/52593 10.1038/s41564-023-01483-y |
| dc.language.none.fl_str_mv | en eng |
| dc.publisher.none.fl_str_mv | Springer Nature |
| dc.relation.none.fl_str_mv | Nature Microbiology. 2023;8 (11):2103-2114 |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess Licencia Creative Commons Atribución (CC - By 4.0) |
| dc.source.none.fl_str_mv | reponame:COLIBRI instname:Universidad de la República instacron:Universidad de la República |
| dc.subject.none.fl_str_mv | CROMATINA CROMOSOMAS GENÉTICA GLICOPROTEÍNAS DE MEMBRANA TRYPANOSOMA BRUCEI BRUCEI TRYPANOSOMA CRUZI |
| dc.title.none.fl_str_mv | Genome-wide chromatin interaction map for Trypanosoma cruzi |
| dc.type.none.fl_str_mv | Artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | Trypanosomes are eukaryotic, unicellular parasites, such as Trypanosoma brucei, which causes sleeping sickness, and Trypanosoma cruzi, which causes Chagas disease. Genomes of these parasites comprise core regions and species-specific disruptive regions that encode multigene families of surface glycoproteins. Few transcriptional regulators have been identified in these parasites, and the role of spatial organization of the genome in gene expression is unclear. Here we mapped genome-wide chromatin interactions in T. cruzi using chromosome conformation capture (Hi-C), and we show that the core and disruptive regions form three-dimensional chromatin compartments named C and D. These chromatin compartments differ in levels of DNA methylation, nucleosome positioning and chromatin interactions, affecting genome expression dynamics. Our data reveal that the trypanosome genome is organized into chromatin-folding domains and transcription is affected by the local chromatin structure. We propose a model in which epigenetic mechanisms affect gene expression in trypanosomes. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | anni_016fa4b8bfb708c3cb1a6997fdb3d9fe |
| identifier_str_mv | Díaz-Viraqué F, Chiribao M, Libisch M y otros. Genome-wide chromatin interaction map for Trypanosoma cruzi. Nature Microbiology [en línea]. 2023;8 (11):2103-2114 2058-5276 10.1038/s41564-023-01483-y |
| instacron_str | Universidad de la República |
| institution | Universidad de la República |
| instname_str | Universidad de la República |
| language | eng |
| language_invalid_str_mv | en |
| network_acronym_str | anni |
| network_name_str | oai-lr-anni |
| oai_identifier_str | oai:colibri.udelar.edu.uy:20.500.12008/52593 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| publisher.none.fl_str_mv | Springer Nature |
| reponame_str | COLIBRI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Licencia Creative Commons Atribución (CC - By 4.0) |
| spelling | Genome-wide chromatin interaction map for Trypanosoma cruziDíaz-Viraqué, FlorenciaChiribao, María LauraLibisch, María GabrielaRobello, CarlosCROMATINACROMOSOMASGENÉTICAGLICOPROTEÍNAS DE MEMBRANATRYPANOSOMA BRUCEI BRUCEITRYPANOSOMA CRUZITrypanosomes are eukaryotic, unicellular parasites, such as Trypanosoma brucei, which causes sleeping sickness, and Trypanosoma cruzi, which causes Chagas disease. Genomes of these parasites comprise core regions and species-specific disruptive regions that encode multigene families of surface glycoproteins. Few transcriptional regulators have been identified in these parasites, and the role of spatial organization of the genome in gene expression is unclear. Here we mapped genome-wide chromatin interactions in T. cruzi using chromosome conformation capture (Hi-C), and we show that the core and disruptive regions form three-dimensional chromatin compartments named C and D. These chromatin compartments differ in levels of DNA methylation, nucleosome positioning and chromatin interactions, affecting genome expression dynamics. Our data reveal that the trypanosome genome is organized into chromatin-folding domains and transcription is affected by the local chromatin structure. We propose a model in which epigenetic mechanisms affect gene expression in trypanosomes.Springer NatureDíaz-Viraqué Florencia, Institut Pasteur de Montevideo (Uruguay)Chiribao María Laura, Universidad de la República (Uruguay). Facultad de MedicinaLibisch María Gabriela, Institut Pasteur de Montevideo (Uruguay)Robello Carlos, Universidad de la República (Uruguay). Facultad de Medicina2025-11-21T17:47:23Z2025-11-21T17:47:23Z2023Artículoinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion19 p.application/pdfDíaz-Viraqué F, Chiribao M, Libisch M y otros. Genome-wide chromatin interaction map for Trypanosoma cruzi. Nature Microbiology [en línea]. 2023;8 (11):2103-21142058-5276https://hdl.handle.net/20.500.12008/5259310.1038/s41564-023-01483-yreponame:COLIBRIinstname:Universidad de la Repúblicainstacron:Universidad de la RepúblicaenengNature Microbiology. 2023;8 (11):2103-2114Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)info:eu-repo/semantics/openAccessLicencia Creative Commons Atribución (CC - By 4.0)oai:colibri.udelar.edu.uy:20.500.12008/525932026-04-14T10:28:22Z |
| spellingShingle | Genome-wide chromatin interaction map for Trypanosoma cruzi Díaz-Viraqué, Florencia CROMATINA CROMOSOMAS GENÉTICA GLICOPROTEÍNAS DE MEMBRANA TRYPANOSOMA BRUCEI BRUCEI TRYPANOSOMA CRUZI |
| status_str | publishedVersion |
| title | Genome-wide chromatin interaction map for Trypanosoma cruzi |
| title_full | Genome-wide chromatin interaction map for Trypanosoma cruzi |
| title_fullStr | Genome-wide chromatin interaction map for Trypanosoma cruzi |
| title_full_unstemmed | Genome-wide chromatin interaction map for Trypanosoma cruzi |
| title_short | Genome-wide chromatin interaction map for Trypanosoma cruzi |
| title_sort | Genome-wide chromatin interaction map for Trypanosoma cruzi |
| topic | CROMATINA CROMOSOMAS GENÉTICA GLICOPROTEÍNAS DE MEMBRANA TRYPANOSOMA BRUCEI BRUCEI TRYPANOSOMA CRUZI |
| url | https://hdl.handle.net/20.500.12008/52593 |