NK cells during dengue disease and their recognition of dengue virus-infected cells
The innate immune response, in addition to the B- and T-cell response, plays a role in protection against dengue virus (DENV) infection and the degree of disease severity. Early activation of natural killer (NK) cells and type-I interferon-dependent immunitymay be important in limiting viral replica...
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| Formato: | article |
| Idioma: | inglés |
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2014
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| Acceso en liña: | http://riicges.gorgas.gob.pa/handle/123456789/62 |
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| _version_ | 1869451841659469824 |
|---|---|
| author | Beltran, Davis |
| author2 | López-Vergès, Sandra |
| author2_role | author |
| author_browse | Beltran, Davis López-Vergès, Sandra |
| author_facet | Beltran, Davis López-Vergès, Sandra |
| author_role | author |
| collection | Repositorio Institucional del Instituto Conmemorativo Gorgas de Estudios de la Salud |
| dc.creator.none.fl_str_mv | Beltran, Davis López-Vergès, Sandra |
| dc.date.none.fl_str_mv | 2014-05-05 2020-01-17T18:35:18Z 2020-01-17T18:35:18Z |
| dc.format.none.fl_str_mv | application/pdf application/pdf |
| dc.identifier.none.fl_str_mv | http://riicges.gorgas.gob.pa/handle/123456789/62 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Frontiers in Immunology |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| dc.source.none.fl_str_mv | reponame:Repositorio Institucional del Instituto Conmemorativo Gorgas de Estudios de la Salud instname:Instituto Conmemorativo Gorgas de Estudios de la Salud instacron:ICGES |
| dc.subject.none.fl_str_mv | dengue NK cell NK receptor NK ligand innate immune response |
| dc.title.none.fl_str_mv | NK cells during dengue disease and their recognition of dengue virus-infected cells |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | The innate immune response, in addition to the B- and T-cell response, plays a role in protection against dengue virus (DENV) infection and the degree of disease severity. Early activation of natural killer (NK) cells and type-I interferon-dependent immunitymay be important in limiting viral replication during the early stages of DENV infection and thus reducing subsequent pathogenesis. NK cells may also produce cytokines that reduce inflammation and tissue injury. On the other hand, NK cells are also capable of inducing liver injury at early-time points of DENV infection. In vitro, NK cells can kill antibody-coated DENVinfected cells through antibody-dependent cell-mediated cytotoxicity. In addition, NK cells may directly recognize DENV-infected cells through their activating receptors, although the increase in HLA class I expression may allow infected cells to escape the NK response. Recently, genome-wide association studies have shown an association between MICB and MICA, which encode ligands of the activating NK receptor NKG2D, and dengue disease outcome.This review focuses on recognition of DENV-infected cells by NK cells and on the regulation of expression of NK cell ligands by DENV. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | PA_295cb2d3cf374a65a455f2bbe6a43021 |
| instacron_str | ICGES |
| institution | ICGES |
| instname_str | Instituto Conmemorativo Gorgas de Estudios de la Salud |
| language | eng |
| network_acronym_str | PA |
| network_name_str | oai la ref anni2 |
| oai_identifier_str | oai:riicges.gorgas.gob.pa:123456789/62 |
| publishDate | 2014 |
| publishDateSort | 2014 |
| publisher.none.fl_str_mv | Frontiers in Immunology |
| reponame_str | Repositorio Institucional del Instituto Conmemorativo Gorgas de Estudios de la Salud |
| repository.mail.fl_str_mv | mail@mail.com |
| repository.name.fl_str_mv |
-
|
| repository_id_str | |
| rights_invalid_str_mv | https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| spelling | NK cells during dengue disease and their recognition of dengue virus-infected cellsBeltran, DavisLópez-Vergès, SandradengueNK cellNK receptorNK ligandinnate immune responseThe innate immune response, in addition to the B- and T-cell response, plays a role in protection against dengue virus (DENV) infection and the degree of disease severity. Early activation of natural killer (NK) cells and type-I interferon-dependent immunitymay be important in limiting viral replication during the early stages of DENV infection and thus reducing subsequent pathogenesis. NK cells may also produce cytokines that reduce inflammation and tissue injury. On the other hand, NK cells are also capable of inducing liver injury at early-time points of DENV infection. In vitro, NK cells can kill antibody-coated DENVinfected cells through antibody-dependent cell-mediated cytotoxicity. In addition, NK cells may directly recognize DENV-infected cells through their activating receptors, although the increase in HLA class I expression may allow infected cells to escape the NK response. Recently, genome-wide association studies have shown an association between MICB and MICA, which encode ligands of the activating NK receptor NKG2D, and dengue disease outcome.This review focuses on recognition of DENV-infected cells by NK cells and on the regulation of expression of NK cell ligands by DENV.The innate immune response, in addition to the B- and T-cell response, plays a role in protection against dengue virus (DENV) infection and the degree of disease severity. Early activation of natural killer (NK) cells and type-I interferon-dependent immunitymay be important in limiting viral replication during the early stages of DENV infection and thus reducing subsequent pathogenesis. NK cells may also produce cytokines that reduce inflammation and tissue injury. On the other hand, NK cells are also capable of inducing liver injury at early-time points of DENV infection. In vitro, NK cells can kill antibody-coated DENVinfected cells through antibody-dependent cell-mediated cytotoxicity. In addition, NK cells may directly recognize DENV-infected cells through their activating receptors, although the increase in HLA class I expression may allow infected cells to escape the NK response. Recently, genome-wide association studies have shown an association between MICB and MICA, which encode ligands of the activating NK receptor NKG2D, and dengue disease outcome.This review focuses on recognition of DENV-infected cells by NK cells and on the regulation of expression of NK cell ligands by DENV.Frontiers in Immunology2020-01-17T18:35:18Z2020-01-17T18:35:18Z2014-05-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://riicges.gorgas.gob.pa/handle/123456789/62enginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/reponame:Repositorio Institucional del Instituto Conmemorativo Gorgas de Estudios de la Saludinstname:Instituto Conmemorativo Gorgas de Estudios de la Saludinstacron:ICGES2020-06-23T16:15:57Zmail@mail.com - |
| spellingShingle | NK cells during dengue disease and their recognition of dengue virus-infected cells Beltran, Davis dengue NK cell NK receptor NK ligand innate immune response |
| status_str | publishedVersion |
| title | NK cells during dengue disease and their recognition of dengue virus-infected cells |
| title_full | NK cells during dengue disease and their recognition of dengue virus-infected cells |
| title_fullStr | NK cells during dengue disease and their recognition of dengue virus-infected cells |
| title_full_unstemmed | NK cells during dengue disease and their recognition of dengue virus-infected cells |
| title_short | NK cells during dengue disease and their recognition of dengue virus-infected cells |
| title_sort | NK cells during dengue disease and their recognition of dengue virus-infected cells |
| topic | dengue NK cell NK receptor NK ligand innate immune response |
| url | http://riicges.gorgas.gob.pa/handle/123456789/62 |